溴化阻燃剂(BFR),常见于消费品中,已被确定为对肝功能的潜在危害。虽然对特定BFR的个体效应有所了解,关于这些化学物质的混合物,尤其是受人口因素影响时,相互作用影响肝功能。这项研究利用了来自国家健康和营养检查调查(2005-2016)的10,828名12岁及以上参与者的数据,以调查BFR(单独和组合)与肝损伤的生物标志物之间的关联。这项研究的重点是年龄,性别,和体重指数(BMI)调节这些影响。多元线性回归,限制三次样条函数,加权分位数和(WQS)回归,和分位数g计算(qgcomp)模型被用来分析线性,非线性,以及BFR水平和肝功能参数之间的联合关联。我们发现混合BFR指数和AST之间存在正相关,ALT,GGT,ALP,和TBIL水平,与ALB水平呈负相关。PBDE28,PBDE47和PBB153始终是WQS和qgcomp模型中的最高权重。最关键的是,研究表明,BFR共同暴露与肝功能参数之间的关系随年龄而改变,性别,BMI。因此,我们的研究强调了在评估BFR诱导的肝损害风险时考虑人口统计学多样性的重要性,并支持实施量身定制的预防和干预策略.
Brominated flame retardants (BFRs), commonly found in consumer products, have been identified as potential hazards to liver function. While the individual effects of specific BFRs are somewhat understood, there is limited evidence on how mixtures of these chemicals, especially when influenced by demographic factors, interact to affect liver function. This study utilized data from 10,828 participants aged 12 and above from the National Health and Nutrition Examination Survey (2005-2016) to investigate the associations between BFRs (both individually and in combinations) and biomarkers of liver injury. The study focused on how age, gender, and body mass index (BMI) modify modulate these effects. Multivariate linear regression, restricted cubic spline function, weighted quantile sum (WQS) regression, and quantile g-computation (qgcomp) models were used to analyze the linear, non-linear, and joint associations between BFR levels and liver function parameters. We found positive associations between the mixed BFRs index and AST, ALT, GGT, ALP, and TBIL levels and a negative association with ALB levels. PBDE28, PBDE47, and PBB153 consistently contributed to the top weight in both the WQS and qgcomp models. Most critically, the study demonstrated that the relationship between co-exposure to BFRs and liver function parameters was modified by age, gender, and BMI. Therefore, our study highlights the importance of considering demographic diversity in assessing the risk of BFR-induced liver damage and supports the implementation of tailored preventive and intervention strategies.