在这个以人口为基础的7538名成年人队列中，联合免疫球蛋白（Ig）G，IgA,严重急性呼吸综合征冠状病毒2（SARS-CoV-2）疫苗接种后测得的IgM（IgG/A/M）抗峰滴度可预测对突破性SARS-CoV-2感染的保护作用。通过调整影响SARS-CoV-2暴露风险的因素，歧视得到了显着改善，包括家庭过度拥挤，公共交通使用,参观室内公共场所。抗标IgG/A/M滴度与中和抗体滴度呈正相关(rs=0.80[95%置信区间,.72-.86]；P<.001）和S肽刺激的干扰素-γ浓度（rs=0.31[.13-.47]；P<.001）。
In this population-based cohort of 7538 adults, combined immunoglobulin (Ig) G, IgA, and IgM (IgG/A/M) anti-spike titers measured after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination were predictive of protection against breakthrough SARS-CoV-2 infection. Discrimination was significantly improved by adjustment for factors influencing risk of SARS-CoV-2 exposure, including household overcrowding, public transport use, and visits to indoor public places. Anti-spike IgG/A/M titers showed positive correlation with neutralizing antibody titers (rs = 0.80 [95% confidence interval, .72-.86]; P < .001) and S peptide-stimulated interferon-γ concentrations (rs = 0.31 [.13-.47]; P < .001).
