{Reference Type}: Journal Article
{Title}: Correlation Between Postvaccination Anti-Spike Antibody Titers and Protection Against Breakthrough Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Population-Based Longitudinal Study.
{Author}: Vivaldi G;Jolliffe DA;Faustini S;Shields AM;Holt H;Perdek N;Talaei M;Tydeman F;Chambers ES;Cai W;Li W;Gibbons JM;Pade C;McKnight Á;Shaheen SO;Richter AG;Martineau AR;
{Journal}: J Infect Dis
{Volume}: 226
{Issue}: 11
{Year}: 11 2022 28
{Factor}: 7.759
{DOI}: 10.1093/infdis/jiac321
{Abstract}: In this population-based cohort of 7538 adults, combined immunoglobulin (Ig) G, IgA, and IgM (IgG/A/M) anti-spike titers measured after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination were predictive of protection against breakthrough SARS-CoV-2 infection. Discrimination was significantly improved by adjustment for factors influencing risk of SARS-CoV-2 exposure, including household overcrowding, public transport use, and visits to indoor public places. Anti-spike IgG/A/M titers showed positive correlation with neutralizing antibody titers (rs = 0.80 [95% confidence interval, .72-.86]; P < .001) and S peptide-stimulated interferon-γ concentrations (rs = 0.31 [.13-.47]; P < .001).