%0 Journal Article
%T Correlation Between Postvaccination Anti-Spike Antibody Titers and Protection Against Breakthrough Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Population-Based Longitudinal Study.
%A Vivaldi G
%A Jolliffe DA
%A Faustini S
%A Shields AM
%A Holt H
%A Perdek N
%A Talaei M
%A Tydeman F
%A Chambers ES
%A Cai W
%A Li W
%A Gibbons JM
%A Pade C
%A McKnight Á
%A Shaheen SO
%A Richter AG
%A Martineau AR
%J J Infect Dis
%V 226
%N 11
%D 11 2022 28
%M 35906930
%F 7.759
%R 10.1093/infdis/jiac321
%X In this population-based cohort of 7538 adults, combined immunoglobulin (Ig) G, IgA, and IgM (IgG/A/M) anti-spike titers measured after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination were predictive of protection against breakthrough SARS-CoV-2 infection. Discrimination was significantly improved by adjustment for factors influencing risk of SARS-CoV-2 exposure, including household overcrowding, public transport use, and visits to indoor public places. Anti-spike IgG/A/M titers showed positive correlation with neutralizing antibody titers (rs = 0.80 [95% confidence interval, .72-.86]; P < .001) and S peptide-stimulated interferon-γ concentrations (rs = 0.31 [.13-.47]; P < .001).