cognitive abilities

认知能力
  • 文章类型: Journal Article
    这项研究旨在检查诊断为轻度认知障碍(MCI)的个体的特定睡眠参数与认知功能的特定方面之间的关联。与健康对照(HC)相比,使用认知,主观,和客观的睡眠措施。共有179名参与者参加,所有年龄≥65岁(平均年龄=70.23;SD=4.74),且至少接受过6年教育(平均值=12.35;SD=3.22).样本包括46例HCs(36例女性),75名患者患有遗忘型MCI(aMCI)(51名女性),58例非遗忘型MCI(naMCI)患者(39例女性)。抑制,认知灵活性作为抑制性控制和集合移位或任务/规则切换的组合应用,并对规划进行了检查。进行以下D-KEFS子测试以进行评估:言语流利度测试,颜色字干涉测试,塔测试。自我报告睡眠问卷(雅典失眠量表,停止-邦问卷,和匹兹堡睡眠质量指数)用于主观睡眠评估。活动描记术用于客观睡眠测量。混合措施方差分析,MANOVA,和单向方差分析,以及Scheffe事后测试,应用于数据。结果显示,三组在塔式测验中表现出统计学上的显著差异(总成就得分,管理的问题总数,和完全违反规则)。关于客观的睡眠测量,总睡眠时间(TST)是使用肌动描记术测量的,并表明存在显著差异,HC组的平均TST明显高于naMCI组。发现在TST塔测试中评估的关系具有统计学意义。在潜在参数的背景下讨论了这些发现,这些参数可以支持睡眠持续时间之间的联系,测量为TST,和认知规划,使用塔测试测量。
    This study aimed to examine the associations between specific sleep parameters and specific aspects of cognitive functioning in individuals diagnosed with mild cognitive impairment (MCI), compared with healthy controls (HCs) by using cognitive, subjective, and objective sleep measures. A total of 179 participants were enrolled, all aged ≥ 65 years (mean age = 70.23; SD = 4.74) and with a minimum of six years of education (mean = 12.35; SD = 3.22). The sample included 46 HCs (36 females), 75 individuals with amnestic MCI (aMCI) (51 females), and 58 individuals with non-amnestic MCI (naMCI) (39 females). Inhibition, cognitive flexibility as a combined application of inhibitory control and set shifting or task/rule switching, and planning were examined. The following D-KEFS subtests were administered for their evaluation: Verbal Fluency Test, Color-Word Interference Test, and Tower Test. Self-reported sleep questionnaires (Athens Insomnia Scale, Stop-Bang questionnaire, and Pittsburg Sleep Quality Index) were used for subjective sleep assessments. Actigraphy was used for objective sleep measurements. Mixed-measures ANOVA, MANOVA, and one-way ANOVA, as well as the Scheffe post hoc test, were applied to the data. The results showed that the three groups exhibited statistically significant differences in the Tower Test (total achievement score, total number of administered problems, and total rule violations). As regards objective sleep measurements, the total sleep time (TST) was measured using actigraphy, and indicated that there are significant differences, with the HC group having a significantly higher mean TST compared to the naMCI group. The relationships evaluated in the TST Tower Test were found to be statistically significant. The findings are discussed in the context of potential parameters that can support the connection between sleep duration, measured as TST, and cognitive planning, as measured using the Tower Test.
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  • 文章类型: Journal Article
    背景:本研究旨在评估24周适度有氧运动对血脂和脂蛋白水平的影响;Lipo(a)标志物,以及它们与健康老年人认知能力的关系。
    方法:本研究共招募了150名健康受试者(100名男性和50名女性;年龄范围:65-95岁)。根据LOTCA考试成绩,研究对象分为对照组(n=50)和认知障碍组(n=100)。认知功能,休闲体育活动(LTPA),血脂谱,总胆固醇,TG,HDL-c,LDL-C,和lipo(a)在基线和24周后使用LOTCA电池进行有氧运动干预,预先验证的全球身体活动问卷(GPAQ)版本II,比色法,和免疫测定技术,分别。
    结果:据报道,在所有年龄较大的受试者中,经过24周的适度运动后,他们的认知功能以及血脂和脂蛋白(a)标志物的调节均有显著改善。LOTCA-7组得分与身体活动状态以及脂质和Lipo(a)标志物的调节显着相关。身体活跃的人表现出更高的认知能力,同时T-Cholest的水平降低。,TG,LDL-C,Lipo(a),与久坐的参与者相比,HDL-C水平和有氧健身VO2max增加。认知表现与有氧健身增加呈正相关,HDL-C,和消极的T-Cholest。,TG,LDL-C,和Lipo(a)。然而,运动实践的显著提高,血管舒缩组织,思考行动,注意,和浓度在老年人中报告。
    结论:研究结果显示,24周的有监督的适度有氧训练通过减轻老年人的血脂和脂蛋白(a)显著增强认知功能。认知表现与有氧适应性和HDL-C水平呈正相关,与T-Cholest呈负相关。,TH,LDL-C,和Lipo(a)。
    BACKGROUND: The present study aimed to evaluate the effects of 24 weeks of moderate aerobic exercise on lipids and lipoprotein levels; Lipo (a) markers, and their association with cognitive performance in healthy older adults.
    METHODS: A total of 150 healthy subjects (100 males and 50 females; age range: 65-95 years) were recruited for this study. Based on the LOTCA test score, subjects were classified into two groups: the control group (n = 50) and the cognitive impairment group (n = 100). Cognitive functioning, leisure-time physical activity (LTPA), lipid profile, total cholesterol, TG, HDL-c, LDL-C, and lipo(a) were assessed at baseline and post-24-week aerobic exercise interventions using LOTCA battery, pre-validated Global Physical Activity Questionnaire (GPAQ) version II, colorimetric, and immunoassay techniques, respectively.
    RESULTS: Significant improvements in cognitive function and modulation in lipid profile and lipoprotein (a) markers were reported in all older subjects following 24 weeks of moderate exercise. LOTCA-7-sets scores significantly correlated with physical activity status and the regulation of lipids and Lipo (a) markers. Physically active persons showed higher cognitive performance along with a reduction in the levels of T-Cholest., TG, LDL-C, Lipo (a), and an increase in the levels of HDL-C and aerobic fitness VO2max compared with sedentary participants. Cognitive performance correlated positively with increased aerobic fitness, HDL-C, and negatively with T-Cholest., TG, LDL-C, and Lipo (a). However, a significant increase in the improvement of motor praxis, vasomotor organization, thinking operations, attention, and concentration were reported among older adults.
    CONCLUSIONS: The study findings revealed that supervised moderate aerobic training for 24 weeks significantly enhances cognitive functions via mitigating older adults\' lipid profiles and lipoprotein (a). Cognitive performance is positively correlated with aerobic fitness and HDL-C level and negatively with T-Cholest., TH, LDL-C, and Lipo (a).
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  • 文章类型: Journal Article
    本研究研究了美国东南部一所中学八年级学生的有氧和无氧运动对认知能力的影响。众所周知,年轻人不符合建议的体育锻炼水平,然而,有研究表明,有氧运动和学习成绩之间有明显的联系。关于无氧运动和认知能力的证据存在差距。如果专业人士知道哪种类型的运动最有利于增强青少年的认知,他们应该在学生的整个上学日将这些做法纳入体育教育和其他领域。因此,这项研究旨在回答以下问题:有氧运动和无氧运动对八年级学生的认知功能有什么影响,特别是测量工作记忆,注意,和冲动?50名研究参与者(N=31名男性,18名女性,1其他),13-14岁,同意/同意完整的研究方案。参与者在参与三种不同的运动条件后,进行了一项包含三种不同认知任务的实验。认知测量是Stroop颜色词任务,侧卫测试,和Go/NoGo任务,它们都测量了反应时间和正确反应的数量。运动条件是基线(不运动后),有氧运动(在PE连续跑步活动后),和无氧(在PE中完成间隔哑铃锻炼后)。每个条件都在单独的一天发生,以减少混杂变量的影响。使用MANOVA的Scheffe修改来分析数据,以确定自变量的多个水平是否影响因变量(反应时间和正确响应的数量)或变量的组合是否影响结果。每个认知测试分别进行分析。结果表明,运动条件确实显着影响了Stroop颜色词任务的反应时间和正确响应的数量[F(4,254)=8.59,p<0.001;Pillai\'sTrace=0.24]。具体来说,与基线相比,有氧运动改善了反应时间(p<0.001)和正确反应的数量(p=0.001),与基线相比,无氧运动改善了反应时间。要了解有关受锻炼计划影响的特定因变量的更多详细信息,进行了单独的方差分析测试,导致关于程序的正确响应次数和反应时间的统计学意义。正确响应数量的部分Eta2为0.07,反应时间为0.24,表明正确响应的方差为7%,反应时间的方差为24%,可以通过锻炼程序来解释。虽然两者都很重要,反应时间比正确的反应受锻炼计划的影响更大。鉴于这些发现,建议在分配认知挑战性任务之前在学校提供有氧体育活动,而快速无氧活动休息应该用来重新集中学生的注意力。应该进行更多的研究来检查其他认知能力,以及其他人群。
    The present study examined the impact of aerobic and anaerobic exercise on cognitive abilities in eighth grade students at one middle school in southeastern US. It is known that youth do not meet recommended physical activity levels, yet there is research demonstrating a clear connection between aerobic exercise and academic performance. There is a gap in evidence regarding anaerobic exercise and cognitive capabilities. If professionals know which type of exercise is most beneficial for enhancing cognition in youth, it will behoove them to incorporate these practices in physical education and other areas throughout the school day for students. Thus, this research aimed to answer the following question: what is the effect of both aerobic and anaerobic exercise on the cognitive functions of eighth grade students, specifically measuring working memory, attention, and impulsivity? Fifty research participants (N = 31 males, 18 females, 1 other), aged 13-14, consented/assented to the complete study protocols. Participants engaged in an experiment containing three different cognitive tasks after partaking in three separate exercise conditions. The cognitive measures were the Stroop color-word task, the Flanker test, and the Go/No Go task, which all measured reaction time and the number of correct responses. The exercise conditions were baseline (after no exercise), aerobic (after a continuous running activity in PE), and anaerobic (after completing an interval dumbbell workout in PE). Each condition took place on a separate day to decrease the effect of confounding variables. The data were analyzed using the Scheffe modification of the MANOVA to determine whether multiple levels of the independent variable influenced the dependent variables (the reaction time and number of correct responses) or if a combination of variables influenced the outcomes. Each cognitive test was analyzed separately. The results showed that the exercise condition did significantly impact the reaction time and the number of correct responses for the Stroop color-word task [F(4, 254) = 8.59, p < 0.001; Pillai\'s Trace = 0.24]. Specifically, aerobic exercise improved both reaction time (p < 0.001) and the number of correct responses (p = 0.001) compared to baseline, while anaerobic exercise improved just reaction time compared to baseline. To find out more detailed information about the specific dependent variable affected by the exercise program, individual ANOVA tests were conducted, resulting in statistical significance for both the number of correct responses and reaction time regarding the program. The partial Eta2 of 0.07 for the number of correct responses and 0.24 for reaction time indicated that 7% of the variance in correct responses and 24% of the variance in reaction time could be explained by the exercise program. While both are significant, reaction time is more impacted by exercise program than correct responses are. Given these findings, it is recommended that aerobic physical activity be offered in school prior to assigning cognitively challenging tasks, while quick anaerobic activity breaks should be used to refocus students\' attention. More research should be conducted to examine other cognitive abilities, as well as in other populations.
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  • 文章类型: Journal Article
    背景:以前的不同研究表明,嗅觉功能可以预测几种类型的认知障碍,特别是与神经退行性疾病有关。然而,关于气味阈值(OT)的作用只有很少的数据,气味鉴别(OD),和气味识别(OI)作为认知障碍的预测因子。这项研究的目的是评估健康受试者的嗅觉功能的每个因素与蒙特利尔认知评估(MoCA)测试的每个特定认知域之间的潜在相关性。
    方法:Sniffin\'Sticks和MoCA测试用于确定嗅觉功能和认知能力,分别。
    结果:在男性中,在OT与语言指数得分以及OI与语言和高管指数得分中发现了显着的相关性,而在女性中,OD和OI与视觉空间指数得分相关。
    结论:我们的数据表明嗅觉功能(OT,OD,和OI)可以被认为是与性别和年龄相关的认知障碍的预测因子。
    BACKGROUND: Different previous studies indicated olfactory function as a predictor of several types of cognitive impairment, in particular related to neurodegenerative disease. However, scanty data are available on the role of odor threshold (OT), odor discrimination (OD), and odor identification (OI) as a predictor of cognitive impairment. The aim of this study was to evaluate potential correlations between each factor of the olfactory function versus each specific cognitive domain of the Montreal Cognitive Assessment (MoCA) test on healthy subjects in relation to gender and age.
    METHODS: Sniffin\' Sticks and MoCA tests were used to determine olfactory function and cognitive abilities, respectively.
    RESULTS: In men, significant correlations were found in OT versus language index score and OI versus language and executive index score, while in women, OD and OI were correlated to visuospatial index score.
    CONCLUSIONS: Our data suggested that olfactory function (OT, OD, and OI) may be considered a predictor for cognitive impairment in relation to gender and age.
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  • 文章类型: Journal Article
    这项研究的目的是调查社会人口统计学和健康因素如何影响塞尔维亚共和国老年人的认知能力,使用2019年全国健康调查的数据。该研究包括3,743名参与者,其中女性为2,061人(55.1%),男性为1,682人(44.9%)。所有参与者的平均年龄为72(10)岁。研究使用横断面数据的逻辑回归分析教育,社会支持,和医疗保健访问影响认知能力,同时调整人口变量。结果显示,较高的教育水平与较低的记忆和注意力障碍之间存在负相关关系,而最近对专家的访问与相同风险增加正相关。报告记忆和注意力主要困难的参与者比例最高(22.6%)是85-89岁年龄组(p<0.001)。在社会支持和与记忆和注意力相关的问题之间发现了统计学上显著的关系(p<0.001)。社会支持成为保持认知能力的重要因素。讨论强调了在促进认知健康方面需要一种全面的方法,考虑到教育,社会融合,以及获得医疗保健是关键因素。该研究承认其局限性,包括其横断面性质和认知能力自我评估中潜在的主观偏见。未来的研究应该包括纵向研究和更客观的认知能力测量。
    The aim of this study was to investigate how sociodemographic and health factors contribute cognitive abilities in the older population of the Republic of Serbia, using data from the 2019 national health survey. The study included 3,743 participants, of whom 2,061 (55.1%) were women and 1,682 (44.9%) were men. The median age of all participants was 72 (10) years. Study used logistic regression on cross-sectional data to analyze how education, social support, and healthcare access affect cognitive abilities, while adjusting for demographic variables. The results revealed negative associations between higher levels of education and lower odds of experiencing memory and concentration problems, while recent visits to specialists were positively associated with increased risk for the same. The highest percentage of participants (22.6%) reporting major difficulties in memory and concentration were in the age group of 85-89 years (p < 0.001). A statistically significant relationship was found between social support and issues related to memory and concentration (p < 0.001). Social support emerged as a significant factor in preserving cognitive abilities. The discussion underscores the need for a comprehensive approach in promoting cognitive health, taking into account education, social integration, and access to healthcare as key factors. The study acknowledges its limitations, including its cross-sectional nature and potential subjective biases in self-assessment of cognitive abilities. Future research should incorporate longitudinal studies and more objective measures of cognitive abilities.
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  • 文章类型: Journal Article
    认知能力如何影响财务和经济决策是引起经济学关注的重要问题。
    本文利用中国家庭面板研究(CFPS)2010、2014和2018年的调查数据,实证检验了认知技能对中国农村参保决策的影响。
    结果表明,较高的单词能力与较高的社会医疗保险参与率相关,单词和数学能力均导致较高的社会养老金参与率。机理分析发现,认知技能较高的个体在保险决策中更容易受到同伴的影响,和更高的认知技能增加个人收入,使他们能够参加社会保险。对劳动供给行为的进一步调查表明,尽管认知技能对非农业劳动参与有积极影响,认知技能放大了社会保障对劳动力供给的负面影响。
    UNASSIGNED: How cognitive abilities affect financial and economic decision is an important issue that has attracted the attention of economics.
    UNASSIGNED: This paper uses the China Family Panel Studies (CFPS) 2010, 2014, and 2018 survey data to empirically test the impact of cognitive skills on the insurance participation decisions in rural China.
    UNASSIGNED: The results show that higher word ability is correlated to higher social health insurance participation and both word and math ability leads to higher social pension participation. Mechanism analysis reveals that individuals with higher cognitive skills are more likely to be affected by peers in insurance decision, and higher cognitive skills increase personal income that enables them to enroll in the social insurance. Further investigation of labor supply behavior suggests that while cognitive skills positively affect non-agricultural labor participation, cognitive skills amplify the negative effect of social security on labor supply.
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  • 文章类型: Journal Article
    特殊教育技术的发展使新的互动形式成为可能,现在可以帮助学生患有计算障碍。近几十年来,人工智能(AI)已经成为一种有前途的工具,特别是在2001年至2010年期间,为患有计算障碍的个人提供了提高教育质量的途径。因此,人工智能的实施对于满足患有计算障碍的学生的需求至关重要。内容分析技术用于检查涵盖AI对计算障碍的影响及其在帮助教师促进对计算障碍个体的教育方面的潜力的文献。该研究旨在通过深入研究为未来更具包容性的计算障碍教育奠定基础。人工智能集成对教育机构以及与计算障碍斗争的人们产生了巨大的影响。本文强调了AI在改善受计算障碍影响的学生的教育成果方面的重要性。
    New forms of interaction made possible by developments in special educational technologies can now help students with dyscalculia. Artificial intelligence (AI) has emerged as a promising tool in recent decades, particularly between 2001 and 2010, offering avenues to enhance the quality of education for individuals with dyscalculia. Therefore, the implementation of AI becomes crucial in addressing the needs of students with dyscalculia. Content analysis techniques were used to examine the literature covering the influence of AI on dyscalculia and its potential to assist instructors in promoting education for individuals with dyscalculia. The study sought to create a foundation for a more inclusive dyscalculia education in the future through in-depth studies. AI integration has had a big impact on educational institutions as well as people who struggle with dyscalculia. This paper highlights the importance of AI in improving the educational outcomes of students affected by dyscalculia.
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  • 文章类型: Journal Article
    视觉搜索(VS)包括一类任务,我们通常在一天中执行几次,并且需要在干扰因素刺激中有意扫描(有或没有移动眼睛)特定目标(无论是对象还是特征)的环境。在基于实验室或现实世界的环境中进行的实验研究从一个名义的角度提供了对其潜在神经认知机制的见解。鲜为人知但快速增长的准实验和相关研究机构探索了个体差异与VS表现之间的联系。这结合了不同的研究传统,涵盖了部署大量VS任务的研究中广泛的个体差异。因此,在考虑更广泛的文献时,确定单项研究中强调的任何关联是否稳健是一个挑战.然而,系统和全面地阐明这种关系将有助于建立更准确的VS模型,它将突出未来研究的有希望的方向。本系统综述提供了对现有文献的最新和全面综合,这些文献调查了VS任务中常见的性能指标与映射到四类认知能力(短期工作记忆,流体推理,视觉处理和处理速度)和七类性状(五大性状,特质焦虑和自闭症特征)。这两个特征的一致关联(特别是,尽责,自闭症特征和特质焦虑-后者仅限于情绪刺激)和认知能力(尤其是视觉处理)被确定。总的来说,然而,未来研究的信息将受益于检查和报告所有测量工具的可靠性,应用多重性校正,使用互补技术,研究预注册和测试为什么,而不仅仅是如果,某些个体差异与VS表现之间存在稳健的关系。
    Visual search (VS) comprises a class of tasks that we typically perform several times during a day and requires intentionally scanning (with or without moving the eyes) the environment for a specific target (be it an object or a feature) among distractor stimuli. Experimental research in lab-based or real-world settings has offered insight into its underlying neurocognitive mechanisms from a nomothetic point of view. A lesser-known but rapidly growing body of quasi-experimental and correlational research has explored the link between individual differences and VS performance. This combines different research traditions and covers a wide range of individual differences in studies deploying a vast array of VS tasks. As such, it is a challenge to determine whether any associations highlighted in single studies are robust when considering the wider literature. However, clarifying such relationships systematically and comprehensively would help build more accurate models of VS, and it would highlight promising directions for future research. This systematic review provides an up to date and comprehensive synthesis of the existing literature investigating associations between common indices of performance in VS tasks and measures of individual differences mapped onto four categories of cognitive abilities (short-term working memory, fluid reasoning, visual processing and processing speed) and seven categories of traits (Big Five traits, trait anxiety and autistic traits). Consistent associations for both traits (in particular, conscientiousness, autistic traits and trait anxiety - the latter limited to emotional stimuli) and cognitive abilities (particularly visual processing) were identified. Overall, however, informativeness of future studies would benefit from checking and reporting the reliability of all measurement tools, applying multiplicity correction, using complementary techniques, study preregistration and testing why, rather than only if, a robust relation between certain individual differences and VS performance exists.
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  • 文章类型: Journal Article
    背景:我们进行了混合作图和精细作图分析,以确定影响认知能力的起源基因位点。
    方法:我们在7140个不同的西班牙裔和拉丁裔成年人(平均年龄55岁)中估计了整个基因组中局部祖先间隔与5项神经认知测量的关联。我们优先考虑相关基因座中的遗传变异,并测试它们在四个独立队列中的复制。
    结果:我们确定了五种神经认知测量的9个局部祖先相关区域。在所有基因座观察到的与认知功能的关联都有很强的生物学支持,并且在4q12、9p22.1和13q12.13处存在独立复制的统计证据。
    结论:我们的研究发现了多个新基因位点,这些基因与认知功能和痴呆有关。并发现了与祖先相关的遗传变异。它增加了我们对西班牙裔和拉丁裔成年人认知功能的遗传结构的理解,并展示了混合物图谱的力量,以发现影响认知功能的独特单倍型。补充全基因组关联研究。
    结论:我们确定了与5个神经认知特征相关的9个起源染色体区域。在每个相关区域中,我们鉴定了单核苷酸多态性(SNP),至少在某种程度上,混合物信号并在Black的独立样品中进行复制测试,非西班牙裔白人,和西班牙裔/拉丁裔成年人相同或相似的神经认知测试。在9个关联中的3个中观察到优先SNP的独立复制的统计证据,在chr4q12、chr9p22.1和chr13q12.13。在所有基因座上,观察到的认知功能和痴呆的关联有很强的生物学支持,优先考虑基因,如KIT,涉及神经毒性蛋白的自噬清除以及肥大细胞和小胶质细胞介导的炎症;SLC24A2,涉及与学习和记忆相关的突触可塑性;和MTMR6,涉及磷酸肌醇脂类代谢。
    BACKGROUND: We conducted admixture mapping and fine-mapping analyses to identify ancestry-of-origin loci influencing cognitive abilities.
    METHODS: We estimated the association of local ancestry intervals across the genome with five neurocognitive measures in 7140 diverse Hispanic and Latino adults (mean age 55 years). We prioritized genetic variants in associated loci and tested them for replication in four independent cohorts.
    RESULTS: We identified nine local ancestry-associated regions for the five neurocognitive measures. There was strong biological support for the observed associations to cognitive function at all loci and there was statistical evidence of independent replication at 4q12, 9p22.1, and 13q12.13.
    CONCLUSIONS: Our study identified multiple novel loci harboring genes implicated in cognitive functioning and dementia, and uncovered ancestry-relevant genetic variants. It adds to our understanding of the genetic architecture of cognitive function in Hispanic and Latino adults and demonstrates the power of admixture mapping to discover unique haplotypes influencing cognitive function, complementing genome-wide association studies.
    CONCLUSIONS: We identified nine ancestry-of-origin chromosomal regions associated with five neurocognitive traits. In each associated region, we identified single nucleotide polymorphisms (SNPs) that explained, at least in part, the admixture signal and were tested for replication in independent samples of Black, non-Hispanic White, and Hispanic/Latino adults with the same or similar neurocognitive tests. Statistical evidence of independent replication of the prioritized SNPs was observed for three of the nine associations, at chr4q12, chr9p22.1, and chr13q12.13. At all loci, there was strong biological support for the observed associations to cognitive function and dementia, prioritizing genes such as KIT, implicated in autophagic clearance of neurotoxic proteins and on mast cell and microglial-mediated inflammation; SLC24A2, implicated in synaptic plasticity associated with learning and memory; and MTMR6, implicated in phosphoinositide lipids metabolism.
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  • 文章类型: Journal Article
    癫痫患者容易出现认知能力下降,抑郁症,焦虑和其他行为障碍。认知合并症在颞叶癫痫患者中特别常见且特征良好,虽然在癫痫动物中处理不一致。因此,这项研究的目的是确定在癫痫动物模型中是否有良好的认知合并症的证据,特别是在颞叶癫痫的大鼠毛果芸香碱模型中。我们搜索了1990年至2023年之间发表的文献。毛果芸香碱诱发的自发性复发性癫痫发作与认知改变的关联已通过使用各种测试进行了评估:上下文恐惧条件(CFC),新颖的对象识别(NOR),径向和T型迷宫,莫里斯水迷宫(MWM)及其变体。由于方法标准的差异,结果很难结合,雇用的动物数量,和结果衡量。一起来看,然而,分析证实毛果芸香碱诱发的癫痫对大鼠认知有影响,并支持这样的观点,即这是临床前研究中评估认知颞叶癫痫合并症的有效模型。
    Patients with epilepsy are prone to cognitive decline, depression, anxiety and other behavioral disorders. Cognitive comorbidities are particularly common and well-characterized in people with temporal lobe epilepsy, while inconsistently addressed in epileptic animals. Therefore, the aim of this study was to ascertain whether there is good evidence of cognitive comorbidities in animal models of epilepsy, in particular in the rat pilocarpine model of temporal lobe epilepsy. We searched the literature published between 1990 and 2023. The association of spontaneous recurrent seizures induced by pilocarpine with cognitive alterations has been evaluated by using various tests: contextual fear conditioning (CFC), novel object recognition (NOR), radial and T-maze, Morris water maze (MWM) and their variants. Combination of results was difficult because of differences in methodological standards, in number of animals employed, and in outcome measures. Taken together, however, the analysis confirmed that pilocarpine-induced epilepsy has an effect on cognition in rats, and supports the notion that this is a valid model for assessment of cognitive temporal lobe epilepsy comorbidities in preclinical research.
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