PDF(Pubmed)
Abstract：
BACKGROUND: The present study aimed to evaluate the effects of 24 weeks of moderate aerobic exercise on lipids and lipoprotein levels; Lipo (a) markers, and their association with cognitive performance in healthy older adults.
METHODS: A total of 150 healthy subjects (100 males and 50 females; age range: 65-95 years) were recruited for this study. Based on the LOTCA test score, subjects were classified into two groups: the control group (n = 50) and the cognitive impairment group (n = 100). Cognitive functioning, leisure-time physical activity (LTPA), lipid profile, total cholesterol, TG, HDL-c, LDL-C, and lipo(a) were assessed at baseline and post-24-week aerobic exercise interventions using LOTCA battery, pre-validated Global Physical Activity Questionnaire (GPAQ) version II, colorimetric, and immunoassay techniques, respectively.
RESULTS: Significant improvements in cognitive function and modulation in lipid profile and lipoprotein (a) markers were reported in all older subjects following 24 weeks of moderate exercise. LOTCA-7-sets scores significantly correlated with physical activity status and the regulation of lipids and Lipo (a) markers. Physically active persons showed higher cognitive performance along with a reduction in the levels of T-Cholest., TG, LDL-C, Lipo (a), and an increase in the levels of HDL-C and aerobic fitness VO2max compared with sedentary participants. Cognitive performance correlated positively with increased aerobic fitness, HDL-C, and negatively with T-Cholest., TG, LDL-C, and Lipo (a). However, a significant increase in the improvement of motor praxis, vasomotor organization, thinking operations, attention, and concentration were reported among older adults.
CONCLUSIONS: The study findings revealed that supervised moderate aerobic training for 24 weeks significantly enhances cognitive functions via mitigating older adults\' lipid profiles and lipoprotein (a). Cognitive performance is positively correlated with aerobic fitness and HDL-C level and negatively with T-Cholest., TH, LDL-C, and Lipo (a).
METHODS: A total of 150 healthy subjects (100 males and 50 females; age range: 65-95 years) were recruited for this study. Based on the LOTCA test score, subjects were classified into two groups: the control group (n = 50) and the cognitive impairment group (n = 100). Cognitive functioning, leisure-time physical activity (LTPA), lipid profile, total cholesterol, TG, HDL-c, LDL-C, and lipo(a) were assessed at baseline and post-24-week aerobic exercise interventions using LOTCA battery, pre-validated Global Physical Activity Questionnaire (GPAQ) version II, colorimetric, and immunoassay techniques, respectively.
RESULTS: Significant improvements in cognitive function and modulation in lipid profile and lipoprotein (a) markers were reported in all older subjects following 24 weeks of moderate exercise. LOTCA-7-sets scores significantly correlated with physical activity status and the regulation of lipids and Lipo (a) markers. Physically active persons showed higher cognitive performance along with a reduction in the levels of T-Cholest., TG, LDL-C, Lipo (a), and an increase in the levels of HDL-C and aerobic fitness VO2max compared with sedentary participants. Cognitive performance correlated positively with increased aerobic fitness, HDL-C, and negatively with T-Cholest., TG, LDL-C, and Lipo (a). However, a significant increase in the improvement of motor praxis, vasomotor organization, thinking operations, attention, and concentration were reported among older adults.
CONCLUSIONS: The study findings revealed that supervised moderate aerobic training for 24 weeks significantly enhances cognitive functions via mitigating older adults\' lipid profiles and lipoprotein (a). Cognitive performance is positively correlated with aerobic fitness and HDL-C level and negatively with T-Cholest., TH, LDL-C, and Lipo (a).
摘要：
背景：本研究旨在评估24周适度有氧运动对血脂和脂蛋白水平的影响；Lipo（a）标志物，以及它们与健康老年人认知能力的关系。
方法：本研究共招募了150名健康受试者（100名男性和50名女性；年龄范围：65-95岁）。根据LOTCA考试成绩,研究对象分为对照组(n=50)和认知障碍组(n=100)。认知功能，休闲体育活动（LTPA），血脂谱,总胆固醇,TG,HDL-c,LDL-C,和lipo（a）在基线和24周后使用LOTCA电池进行有氧运动干预，预先验证的全球身体活动问卷（GPAQ）版本II，比色法,和免疫测定技术，分别。
结果：据报道，在所有年龄较大的受试者中，经过24周的适度运动后，他们的认知功能以及血脂和脂蛋白（a）标志物的调节均有显著改善。LOTCA-7组得分与身体活动状态以及脂质和Lipo（a）标志物的调节显着相关。身体活跃的人表现出更高的认知能力，同时T-Cholest的水平降低。,TG,LDL-C,Lipo(a),与久坐的参与者相比，HDL-C水平和有氧健身VO2max增加。认知表现与有氧健身增加呈正相关，HDL-C,和消极的T-Cholest。,TG,LDL-C,和Lipo（a）。然而,运动实践的显著提高，血管舒缩组织,思考行动，注意,和浓度在老年人中报告。
结论：研究结果显示，24周的有监督的适度有氧训练通过减轻老年人的血脂和脂蛋白（a）显著增强认知功能。认知表现与有氧适应性和HDL-C水平呈正相关，与T-Cholest呈负相关。,TH,LDL-C,和Lipo（a）。
方法：本研究共招募了150名健康受试者（100名男性和50名女性；年龄范围：65-95岁）。根据LOTCA考试成绩,研究对象分为对照组(n=50)和认知障碍组(n=100)。认知功能，休闲体育活动（LTPA），血脂谱,总胆固醇,TG,HDL-c,LDL-C,和lipo（a）在基线和24周后使用LOTCA电池进行有氧运动干预，预先验证的全球身体活动问卷（GPAQ）版本II，比色法,和免疫测定技术，分别。
结果：据报道，在所有年龄较大的受试者中，经过24周的适度运动后，他们的认知功能以及血脂和脂蛋白（a）标志物的调节均有显著改善。LOTCA-7组得分与身体活动状态以及脂质和Lipo（a）标志物的调节显着相关。身体活跃的人表现出更高的认知能力，同时T-Cholest的水平降低。,TG,LDL-C,Lipo(a),与久坐的参与者相比，HDL-C水平和有氧健身VO2max增加。认知表现与有氧健身增加呈正相关，HDL-C,和消极的T-Cholest。,TG,LDL-C,和Lipo（a）。然而,运动实践的显著提高，血管舒缩组织,思考行动，注意,和浓度在老年人中报告。
结论：研究结果显示，24周的有监督的适度有氧训练通过减轻老年人的血脂和脂蛋白（a）显著增强认知功能。认知表现与有氧适应性和HDL-C水平呈正相关，与T-Cholest呈负相关。,TH,LDL-C,和Lipo（a）。
