背景:已知吸烟会导致内皮功能障碍和支气管癌,并且吸烟持续时间与吸烟对常规吸烟者的影响有关。这项研究评估了长期吸烟对慢性吸烟者某些凝血指标的影响。
方法:共有78名慢性吸烟者(年龄,41±20年),根据吸烟时间(2-6年,7-11年,12-16岁和17-21岁),并包括在研究中。出血时间(BT),全血凝血时间(WBCT),总血小板计数(TPC),使用标准手术程序估计受试者的凝血酶原时间(PT)和高岭土活化部分凝血活酶时间(APTTK)。
方法:使用Graphpadprism软件(Statmate)2.0版和SPSS20.0版进行统计分析,并使用配对Student'st检验计算显著性检验。
结果:吸烟持续时间与BT呈负相关,WBCT,PT和APTTK凝血标志物以及不同持续时间与TPC之间的线性相关,慢性吸烟者。影响最强的是12-16年和17-21年(P<0.05)。
结论:研究表明,长期慢性吸烟可导致慢性吸烟者的止血功能障碍。吸烟通常应该被劝阻,因为它可能对这组受试者产生深远的医学影响,尤其是在出血紧急情况下。
BACKGROUND: Smoking has been known to cause endothelial dysfunction and bronchial carcinoma and duration of smoking has been implicated in the effects of smoking on regular smokers. This study evaluated the effects of long-term smoking on some coagulation markers in chronic smokers.
METHODS: A total of 78 chronic smokers (age, 41 ± 20 years) where grouped according to duration of time they have smoked (2-6 years, 7-11 years, 12-16 years and 17-21 years), and included in the study. Bleeding time (BT), whole-blood clotting time (WBCT), total platelet count (TPC), prothrombin time (PT) and activated partial thromboplastin time with kaolin (APTTK) were estimated in the subjects using standard operative procedures.
METHODS: Graph pad prism software (Statmate) version 2.0 and SPSS version 20.0 were used for the statistical analysis and the test of significance was calculated using paired Student\'s t-test.
RESULTS: There was an inverse correlation between the durations of smoking and BT, WBCT, PT and APTTK coagulation markers and a linear correlation between the different durations and TPC, in the chronic smokers. The strongest effects was in the 12-16 years and 17-21 years duration (P < 0.05).
CONCLUSIONS: The study revealed that long-term chronic cigarette-smoking can lead to haemostatic dysfunction in chronic smokers. Smoking should be generally discouraged as it could have far-reaching medical implications on this group of subjects, especially in bleeding emergency cases.