PDF(Pubmed)
Abstract：
Introduction Chronic proton-pump inhibitor (PPI) prescription is on the rise in the last decade with an increased prevalence in the elderly population. For most patients, this class of drugs is the primary treatment for various diseases. Even though PPIs are generally safe, long-term use has been associated with multiple adverse effects like bone fractures. The extent of the association between PPI and fracture is still unclear in women aged between 50 and 65 years. Besides, many other variables and risk factors must be accounted for in the analysis of this relation. Methods This is a retrospective case-control study looking at women 50-65 years of age who presented to Genesys Health for a low-impact fall. Data were extracted from electronic medical records and fracture outcomes; PPI therapy exposure and duration were determined. Chi-square analysis was performed to determine the association between chronic PPI therapy and fracture outcome and independently analyzed for major risk factors of osteoporosis, including smoking, low body mass index, and cancer. Results Patients in the chronic PPI therapy group were found to have a decreased fracture outcome overall in each subcategory of risk factors. When adjusting for all risk factors, there was a significant but weak association between chronic PPI therapy and increased fracture outcome. Conclusion With different results from previous studies, this study sheds new light on this debate. More studies need to be carried out to determine the association between chronic PPI therapy and fracture outcomes in postmenopausal women.
摘要：
简介慢性质子泵抑制剂（PPI）处方在过去十年中呈上升趋势，老年人口患病率增加。对于大多数患者来说,这类药物是各种疾病的主要治疗方法。尽管PPI通常是安全的，长期使用与多种不良反应如骨折有关.年龄在50至65岁之间的女性中，PPI与骨折之间的关联程度仍不清楚。此外,在分析这种关系时，必须考虑许多其他变量和风险因素。方法：这是一项回顾性病例对照研究，研究年龄在50-65岁之间的女性，她们接受GenesysHealth的低影响跌倒。从电子病历和骨折结果中提取数据；确定PPI治疗暴露量和持续时间。进行卡方分析以确定慢性PPI治疗与骨折结局之间的关系，并独立分析骨质疏松症的主要危险因素。包括吸烟,低体重指数，和癌症。结果发现慢性PPI治疗组的患者在每个危险因素亚类中总体骨折结局下降。当调整所有风险因素时，慢性PPI治疗与骨折结局增加之间存在显著但弱的关联.结论与以往的研究结果不同,这项研究为这场辩论提供了新的思路。需要进行更多的研究来确定慢性PPI治疗与绝经后妇女骨折结局之间的关系。
