背景:决明子精液,属于豆科,来自决明子或决明子的干成熟种子,长期以来一直用作泻药,保肝,改善视力,以及亚洲的抗糖尿病并发症药物或功能性食品。
目的:本文综述了植物学的综合研究进展,传统用途,植物化学,药理学,毒性,决明子的质量控制。此外,还讨论了新出现的挑战和可能的发展方向。
方法:关于决明子的信息是从发表的科学材料中收集的,包括中医古籍;博士和硕士。论文;药用植物专著;各国药典和电子数据库,比如PubMed,WebofScience,ACS,科学直接,J-STAGE,施普林格链接,泰勒,CNKI和谷歌学者,等。结果:首先,概述了决明子的传统用途和植物来源。其次,大约137种化合物,包括蒽醌,萘并吡喃酮,萘,黄酮,多糖和其他化合物,已从决明子和决明子中分离和鉴定,综述了决明子粗提物及其主要生物活性化合物的药理活性和作用机制。此外,处理,毒性,并简要介绍了质量控制。
结论:决明子是一种常用的中药,药理作用主要影响消化系统,心血管系统和神经系统。这篇综述总结了其植物学,传统用途,植物化学,和药理学,它还展示了最近的科学研究进展和差距,这对决明子的理解和应用提供了更深入的见解。在决明子精液的未来研究中,萘并吡喃酮和多糖的药理活性以及改善眼部疾病的作用机制应给予更多关注。同时,重点加强药物代谢动力学研究和相关保健品的安全性评价研究。
BACKGROUND: Cassiae Semen, belonging to the family Leguminosae, is derived from the dry mature seeds of Cassia obtusifolia L. or Cassia tora L. and has long been used as a laxative, hepatoprotective, improve eyesight, and antidiabetic complications medicine or functional food in Asia.
OBJECTIVE: This review summarizes the integrated research progress of botany, traditional uses, phytochemistry, pharmacology, toxicity, and quality control of Cassiae Semen. Additionally, the emerging challenges and possible developing directions are discussed as well.
METHODS: The information on Cassiae Semen was collected from published scientific materials, including ancient books of traditional Chinese Medicine; Ph.D. and M. Sc. dissertations; monographs on medicinal plants; pharmacopoeia of various countries and electronic databases, such as PubMed, Web of Science, ACS, Science Direct, J-STAGE, Springer link, Taylor, CNKI and Google Scholar, etc. RESULTS: First, the traditional uses and plant origins of Cassiae Semen are outlined. Secondly, approximately 137 compounds, including anthraquinones, naphthopyranones, naphthalenes, flavones, polysaccharides and other compounds, have been isolated and identified from Cassia obtusifolia L. and Cassia tora L. Third, the pharmacological activities and mechanisms of crude extract of Cassiae Semen and its main bioactive compounds are summarized. Moreover, the processing, toxicity, and quality control are introduced briefly.
CONCLUSIONS: Cassiae Semen is a frequently used Chinese Materia Medica with pharmacological effects that mainly affect the digestive system, cardiovascular systems and nervous system. This review summarized its botany, traditional uses, phytochemistry, and pharmacology, it also exhibited recent scientific research advances and gaps, which provide a deeper insight into the understanding and application of Cassiae Semen. In future research on Cassiae Semen, more attention should be given to the pharmacological activities of naphthopyranones and polysaccharides and the mechanism of action for improving eye diseases. Meanwhile, it is essential to focus on strengthening the study on the pharmacokinetics research and the safety evaluation of related health products research.