■输血仍然是必不可少的治疗干预措施,但是输血反应的发生使其管理更加复杂。血液制品接受者对此类反应的警惕报告对于有效的血液警惕至关重要。本研究旨在确定输血反应的频率和性质。
■在拉巴特地区输血中心的血液警戒部门进行了五年(2017-2021年),这项回顾性研究利用了卫生机构通知的事件表格和地区输血中心计算机系统的数据。
■从2017年1月1日至2021年12月31日,拉巴特地区输血中心向各种医疗机构分发了435,651种不稳定的血液制品,报告了191例输血反应,涉及191例患者。患者的中位年龄为44.3岁,输血反应的总累积发生率为0.44/1000不稳定血液制品。主要反应是非溶血性发热和过敏反应,占比分别为41.36%和35.60%。1级反应占记录的所有反应的87%。在学习期间,记录了三人死亡,ABO不相容和输血相关急性肺损伤(TRALI)分别占2例和1例。涉及红细胞成分的输血反应明显比涉及血小板和血浆成分的输血反应更为频繁。
■这项研究显示输血反应的发生率相对较低(0.44%),以非溶血性发热和过敏反应为主。确定了几个级别的故障,特别是对输血实践和血液警惕方面的反应报告不足和培训不足,以及需要一个有效的电子输血反应报告系统,以促进报告和识别潜在问题和危险因素,以提高向患者提供的输血护理质量。
UNASSIGNED: blood transfusion remains an essential therapeutic intervention, but the occurrence of transfusion reactions makes its administration even more complex. Vigilant reporting of such reactions by recipients of blood products is essential for effective haemovigilance. This study aimed to determine the frequency and nature of transfusion reactions.
UNASSIGNED: conducted over five years (2017-2021) at the Haemovigilance Department of the Rabat Regional Blood Transfusion Centre, this retrospective study exploited incident forms notified by health establishments and data from the regional blood transfusion centre\'s computer system.
UNASSIGNED: from 1 January 2017 and 31 December 2021, the Rabat Regional Blood Transfusion Centre distributed 435,651 labile blood products to various healthcare establishments, which reported 191 transfusion reactions involving 191 patients. The median age of the patients was 44.3 years, with an overall cumulative incidence of transfusion reactions of 0.44 per 1000 labile blood products delivered. The predominant reactions were non-haemolytic febrile and allergic reactions, accounting for 41.36% and 35.60% respectively. Grade 1 reactions accounted for 87% of all reactions recorded. During the study period, three deaths were recorded, with ABO incompatibility and transfusion-related acute lung injury (TRALI) accounting for two and one case respectively. Transfusion reactions involving erythrocyte components were significantly more frequent than those involving platelet and plasma components.
UNASSIGNED: this study revealed a relatively low incidence of transfusion reactions (0.44%), dominated by non-haemolytic febrile and allergic reactions. Several levels of failure were identified, in particular under-reporting of reactions and inadequate training in transfusion practices and haemovigilance, as well as the need for an effective electronic transfusion reaction reporting system to facilitate reporting and identification of underlying problems and risk factors to improve the quality of transfusion care provided to patients.