■这篇叙述性综述旨在更新当前的证据,并提供新的非侵入性超声技术的见解,该技术用于早期识别牙周炎受试者的退行性血管变化,并研究这些方法是否可用于识别牙周炎患者的亚临床心血管疾病(CVD)功能障碍并监测牙周治疗后CVD风险的变化。
■分析了通过最新方法学评估血管内皮功能的研究。系统审查,观察性研究,使用PubMed确定了英语的临床试验,WebofScience,和谷歌学者数据库,其中包含关键搜索词,如“牙周炎”,内皮功能障碍(ED),动脉僵硬度,“和”牙周治疗。
■牙周炎与CVD之间的关联涉及几种机制。关键参与者是牙周细菌及其毒素,可以进入循环并渗入血管壁。促炎分子如白细胞介素和趋化因子的增加,c反应蛋白,纤维蛋白原,而氧化应激也起着决定性的作用。此外,ED参数的增加,动脉僵硬度,和动脉粥样硬化,如颈动脉内膜-中膜厚度,脉搏波速度,和流动介导的扩张,已在牙周患者中显示。
■目前的文献对牙周炎和心血管疾病的相关性以及牙周治疗对全身炎症指标和心血管预后的积极作用达成一致。希望,这些非侵入性方法可以扩展到牙周患者,从牙周个性化医学方法的角度全面了解CVD-牙周炎的联系.
UNASSIGNED: This narrative review aims to update the current evidence and offer insight into the new non-invasive ultrasound techniques used to early identify degenerative vascular changes in subjects with periodontitis and to investigate if these methodologies could be useful to identify subclinical cardiovascular disease (CVD) dysfunction in periodontitis patients and to monitor changes in CVD risk after periodontal treatment.
UNASSIGNED: Studies examining the assessment of vascular endothelial function through the latest methodologies were analyzed. Systematic reviews, observational studies, and clinical trials in the English language were identified using PubMed, Web of Science, and Google Scholar databases with key search terms such as \"periodontitis,\" \"endothelial dysfunction (ED),\" \"arterial stiffness,\" and \"periodontal therapy.\"
UNASSIGNED: Several mechanisms are involved in the association between periodontitis and CVD. The key players are periodontal bacteria and their toxins, which can enter the circulation and infiltrate blood vessel walls. The increase in proinflammatory molecules such as interleukins and chemokines, c-reactive protein, fibrinogen, and oxidative stress also plays a decisive role. In addition, an increase in parameters of ED, arterial stiffness, and atherosclerosis, such as carotid intima-media thickness, pulse wave velocity, and flow-mediated dilatation, has been shown in periodontal patients.
UNASSIGNED: The literature today agrees on the association of periodontitis and CVD and the positive role of periodontal therapy on systemic inflammatory indices and cardiovascular outcomes. Hopefully, these non-invasive methodologies could be extended to periodontal patients to provide a comprehensive understanding of the CVD-periodontitis link from the perspective of a personalized medicine approach in periodontology.