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Abstract：
In light of the post-genomic era, epigenetics brings about an opportunity to better understand how the molecular machinery works and is led by a complex dynamic set of mechanisms, often intricate and complementary in many aspects. In particular, epigenetics links developmental biology and genetics, as well as many other areas of knowledge. The present work highlights substantial scopes and relevant discoveries related to the development of the term from its first notions. To our understanding, the concept of epigenetics needs to be revisited, as it is one of the most relevant and multifaceted terms in human knowledge. To redirect future novel experimental or theoretical efforts, it is crucial to compile all significant issues that could impact human and ecological benefit in the most precise and accurate manner. In this paper, the reader can find one of the widest compilations of the landmarks and epistemic considerations of the knowledge of epigenetics across the history of biology from the earliest epigenetic formulation to genetic determinism until the present. In the present work, we link the current body of knowledge and earlier pre-genomic concepts in order to propose a new definition of epigenetics that is faithful to its regulatory nature.
摘要：
鉴于后基因组时代，表观遗传学带来了一个机会，更好地了解分子机械是如何工作的，并由一套复杂的动态机制领导，在许多方面往往错综复杂，相辅相成。特别是,表观遗传学将发育生物学和遗传学联系起来，以及许多其他领域的知识。本工作重点介绍了与该术语从第一个概念开始发展有关的大量范围和相关发现。根据我们的理解，表观遗传学的概念需要重新审视，因为它是人类知识中最相关和最多方面的术语之一。为了改变未来新的实验或理论努力，以最精确和最准确的方式汇编所有可能影响人类和生态利益的重大问题至关重要。在本文中,从最早的表观遗传学表述到遗传决定论，读者可以找到生物学历史上表观遗传学知识的地标和认识论的最广泛汇编之一。在目前的工作中,我们将当前的知识体系和早期的前基因组概念联系起来，以便提出一种新的表观遗传学定义，该定义忠实于其调控性质。
