通过创新方法解决骨骼异常和疾病的紧迫性导致了工程学的重大跨学科融合,3D打印,以及开发个性化生物陶瓷生物支架的设计。这篇综述探讨了非抗生素抗菌生物陶瓷在骨组织工程中的最新进展和未来发展轨迹。鉴于骨科感染不断升级的挑战,抗生素耐药性,和新兴病原体。最初,这篇综述对细菌之间复杂的相互作用进行了深入的探索,免疫细胞,和临床环境中的生物陶瓷,强调感染动力学的多面性,包括蛋白质吸附,免疫反应,细菌粘附,和内毒素释放。然后,专注于旨在提供多功能的下一代生物陶瓷,特别是在提供独立于传统抗生素的抗菌性能。这项研究的一个关键亮点是探索智能抗菌生物陶瓷,标志着医疗植入技术的革命性进步。该审查还旨在指导生物陶瓷材料的持续开发和临床采用,专注于它们在促进骨骼再生和表现出抗菌性能方面的双重能力。这些下一代生物陶瓷代表了医疗植入技术的范式转变,提供超越传统方法的多功能好处。
The urgency to address skeletal abnormalities and diseases through innovative approaches has led to a significant interdisciplinary convergence of engineering, 3D printing, and design in developing individualised bioceramic bioscaffolds. This review explores into the recent advancements and future trajectory of non-antibiotic antibacterial
bioceramics in bone tissue engineering, an importance given the escalating challenges of orthopaedic infections, antibiotic resistance, and emergent pathogens. Initially, the review provides an in-depth exploration of the complex interactions among bacteria, immune cells, and
bioceramics in clinical contexts, highlighting the multifaceted nature of infection dynamics, including protein adsorption, immunological responses, bacterial adherence, and endotoxin release. Then, focus on the next-generation
bioceramics designed to offer multifunctionality, especially in delivering antibacterial properties independent of traditional antibiotics. A key highlight of this study is the exploration of smart antibacterial
bioceramics, marking a revolutionary stride in medical implant technology. The review also aims to guide the ongoing development and clinical adoption of bioceramic materials, focusing on their dual capabilities in promoting bone regeneration and exhibiting antibacterial properties. These next-generation
bioceramics represent a paradigm shift in medical implant technology, offering multifunctional benefits that transcend traditional approaches.