本文提供了适用于生产受损组织替代品的可用可再吸收生物材料的全面概述。此外,他们的各种性质和应用的可能性也进行了讨论。生物材料是组织工程(TE)支架的基本组成部分,起着至关重要的作用。它们需要表现出生物相容性,生物活性,生物降解性,和无毒性,以确保它们能够以适当的宿主反应有效地发挥作用。随着医疗植入物生物材料的不断研究和进步,这篇综述的目的是探索最近开发的用于各种组织的可植入支架材料。本文对生物材料的分类包括化石基材料(例如,PCL,PVA,PU,PEG,和PPF),天然或生物基材料(例如,HA,PLA,PHB,PHBV,壳聚糖,纤维蛋白,胶原蛋白,淀粉,和水凝胶),和混合生物材料(例如,PCL/PLA,PCL/PEG,PLA/PEG,PLA/PHBPCL/胶原蛋白,PCL/壳聚糖,PCL/淀粉,和PLA/生物陶瓷)。考虑了这些生物材料在硬TE和软TE中的应用,特别关注它们的物理化学,机械,和生物学特性。此外,讨论了支架驱动的组织再生过程中支架与宿主免疫系统之间的相互作用。此外,文章简要提到了原位TE的概念,它利用了受影响组织的自我更新能力,并强调了生物聚合物支架在这一策略中所起的关键作用。
This article provides a thorough overview of the available resorbable biomaterials appropriate for producing replacements for damaged tissues. In addition, their various properties and application possibilities are discussed as well. Biomaterials are fundamental components in tissue engineering (TE) of scaffolds and play a critical role. They need to exhibit biocompatibility, bioactivity, biodegradability, and non-toxicity, to ensure their ability to function effectively with an appropriate host response. With ongoing research and advancements in biomaterials for medical implants, the objective of this
review is to explore recently developed implantable scaffold materials for various tissues. The categorization of biomaterials in this paper includes fossil-based materials (e.g., PCL, PVA, PU, PEG, and PPF), natural or bio-based materials (e.g., HA, PLA, PHB, PHBV, chitosan, fibrin, collagen, starch, and hydrogels), and hybrid biomaterials (e.g., PCL/PLA, PCL/PEG, PLA/PEG, PLA/PHB PCL/collagen, PCL/chitosan, PCL/starch, and PLA/
bioceramics). The application of these biomaterials in both hard and soft TE is considered, with a particular focus on their physicochemical, mechanical, and biological properties. Furthermore, the interactions between scaffolds and the host immune system in the context of scaffold-driven tissue regeneration are discussed. Additionally, the article briefly mentions the concept of in situ TE, which leverages the self-renewal capacities of affected tissues and highlights the crucial role played by biopolymer-based scaffolds in this strategy.