PDF(Pubmed)
Abstract：
Reconstruction of craniomaxillofacial bone defects using 3D-printed hydroxyapatite (HA) bioceramic patient-specific implants (PSIs) is a new technique with great potential. This study aimed to investigate the advantages, disadvantages, and clinical outcomes of these implants in craniomaxillofacial surgeries. The PubMed and Embase databases were searched for patients with craniomaxillofacial bone defects treated with bioceramic PSIs. Clinical outcomes such as biocompatibility, biomechanical properties, and aesthetics were evaluated and compared to those of commonly used titanium or poly-ether-ether-ketone (PEEK) implants and autologous bone grafts. Two clinical cases are presented to illustrate the surgical procedure and clinical outcomes of HA bioceramic PSIs. Literature review showed better a biocompatibility of HA PSIs than titanium and PEEK. The initial biomechanical properties were inferior to those of autologous bone grafts, PEEK, and titanium but improved when integrated. Satisfactory aesthetic results were found in our two clinical cases with good stability and absence of bone resorption or infection. Radiological signs of osteogenesis were observed in the two clinical cases six months postoperatively. HA bioceramic PSIs have excellent biocompatible properties and imitate natural bone biomechanically and radiologically. They are a well-suited alternative for conventional biomaterials in the reconstruction of load-sharing bone defects in the craniomaxillofacial region.
摘要：
使用3D打印的羟基磷灰石（HA）生物陶瓷患者专用植入物（PSIs）重建颅颌面骨缺损是一项具有巨大潜力的新技术。本研究旨在探讨其优势，缺点,以及这些植入物在颅颌面手术中的临床结果。在PubMed和Embase数据库中搜索了接受生物陶瓷PSIs治疗的颅颌面骨缺损患者。临床结果，如生物相容性，生物力学特性，和美学进行了评估，并与常用的钛或聚醚醚酮（PEEK）植入物和自体骨移植物进行了比较。提出了两个临床病例来说明HA生物陶瓷PSIs的外科手术和临床结果。文献综述显示HAPSIs比钛和PEEK具有更好的生物相容性。最初的生物力学特性不如自体骨移植，PEEK,和钛，但在集成时有所改善。在我们的两个临床病例中发现令人满意的美学结果，稳定性好，没有骨吸收或感染。术后六个月在2例临床病例中观察到成骨的放射学征象。HA生物陶瓷PSIs具有优越的生物相容性，在生物力学和放射学上模仿天然骨。在重建颅颌面区域的负载共享骨缺损中，它们是常规生物材料的非常适合的替代品。
