僵人综合征(SPS)是一种罕见的与恶性肿瘤相关的中枢神经系统疾病。在这次审查中,我们从PubMed检索到信息,直到2023年8月,使用各种搜索词及其组合,包括SPS,僵硬的人综合征谱系障碍(SPSSD),副肿瘤,癌症,和恶性肿瘤。组织了以英文印刷的同行评审期刊的数据,以解释不同癌症与SPSSD亚型之间的可能关系。以及相关的自身抗原。从文献检索,据透露,乳腺癌是与SPSSD相关的最普遍的癌症,其次是肺癌和淋巴瘤。此外,经典SPS是最常见的SPSSD亚型,其次是四肢僵硬综合征和进行性脑脊髓炎,伴有僵硬和肌阵挛症。GAD65是癌症和SPSSD患者中最常见的自身抗原,其次是两栖蛋白和GlyR。癌症亚型患者可能有多种SPSSD亚型,反过来,SPSSD亚型患者可能有多种癌亚型.这篇综述的第一个目的是强调癌症之间关系的复杂性。自身抗原,和SPSSD作为该领域的新信息继续在全球范围内生成。采用开放的方法来更新有关新癌症亚型的信息,自身抗原,和SPSSD建议更新我们的数据库。这篇综述的第二个目的是讨论SPS动物模型,这将有助于我们了解SPS发病机制。在未来,阐明癌症之间的关系,自身抗原,和SPSSD对于癌症的早期预测和新的治疗方式的发现至关重要。
Stiff person syndrome (SPS) is a rare central nervous system disorder associated with malignancies. In this review, we retrieved information from PubMed, up until August 2023, using various search terms and their combinations, including SPS, stiff person syndrome spectrum disorders (SPSSDs), paraneoplastic, cancer, and malignant tumor. Data from peer-reviewed journals printed in English were organized to explain the possible relationships between different carcinomas and SPSSD subtypes, as well as related autoantigens. From literature searching, it was revealed that breast cancer was the most prevalent carcinoma linked to SPSSDs, followed by lung cancer and lymphoma. Furthermore, classic SPS was the most common SPSSD subtype, followed by stiff limb syndrome and progressive encephalomyelitis with rigidity and myoclonus. GAD65 was the most common
autoantigen in patients with cancer and SPSSDs, followed by amphiphysin and GlyR. Patients with cancer subtypes might have multiple SPSSD subtypes, and conversely, patients with SPSSD subtypes might have multiple carcinoma subtypes. The first aim of this review was to highlight the complex nature of the relationships among cancers, autoantigens, and SPSSDs as new information in this field continues to be generated globally. The adoption of an open-minded approach to updating information on new cancer subtypes, autoantigens, and SPSSDs is recommended to renew our database. The second aim of this review was to discuss SPS animal models, which will help us to understand the mechanisms underlying the pathogenesis of SPS. In future, elucidating the relationship among cancers, autoantigens, and SPSSDs is critical for the early prediction of cancer and discovery of new therapeutic modalities.