PDF(Pubmed)
Abstract：
Autoantibodies are a common mark of autoimmune reaction and their identification in the patients\' serum, cerebrospinal fluid, or tissues is generally believed to represent diagnostic or prognostic biomarkers of autoimmune diseases or autoinflammatory conditions. Traditionally, autoantibody testing is an important part of the clinical examination of suspected patients, and in the absence of reliable T cell tests, characterization of autoantibody responses might be suitable in finding causes of specific autoimmune responses, their strength, and sometimes commencement of autoimmune disease. Autoantibodies are also useful for prognostic stratification in clinically diverse groups of patients if checked repeatedly. Antibody discoveries are continuing, with important consequences for verifying autoimmune mechanisms, diagnostic feasibility, and clinical management. Adding newly identified autoantibody-autoantigen pairs to common clinical laboratory panels should help upgrade and harmonize the identification of systemic autoimmune rheumatic disorders and other autoimmune conditions. Herein, we aim to summarize our current knowledge of uncommon and novel autoantibodies in the context of discussing their validation, diagnostic practicability, and clinical relevance. The regular updates within the field are important and well justified.
摘要：
自身抗体是患者血清中自身免疫反应及其鉴定的常见标志，脑脊液,或组织通常被认为代表自身免疫疾病或自身炎性病症的诊断或预后性生物标志物。传统上,自身抗体检测是疑似患者临床检查的重要组成部分,在没有可靠的T细胞测试的情况下，自身抗体反应的表征可能适用于寻找特异性自身免疫反应的原因，他们的力量,有时是自身免疫性疾病的开始。如果反复检查，自身抗体也可用于临床不同患者组中的预后分层。抗体的发现仍在继续，对验证自身免疫机制有重要影响，诊断可行性，和临床管理。将新鉴定的自身抗体-自身抗原对添加到普通临床实验室面板应有助于升级和协调系统性自身免疫性风湿性疾病和其他自身免疫性疾病的鉴定。在这里，我们的目的是在讨论其验证的背景下，总结我们目前对不常见和新型自身抗体的知识，诊断实用性，和临床相关性。该领域内的定期更新是重要且合理的。
