Abstract：
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system resulting from loss of immune tolerance. Many disease-modifying therapies for MS have broad immunosuppressive effects on peripheral immune cells, but this can increase risks of infection and attenuate vaccine-elicited immunity. A more targeted approach is to re-establish immune tolerance in an autoantigen-specific manner. This review discusses methods to achieve this, focusing on tolerogenic dendritic cells. Clinical trials in other autoimmune diseases also provide learnings with regards to clinical translation of this approach, including identification of autoantigen(s), selection of appropriate patients and administration route and frequency.
摘要：
多发性硬化(MS)是一种因失去免疫耐受而引起的中枢神经系统的慢性炎性脱髓鞘疾病。许多MS的疾病修饰疗法对外周免疫细胞具有广泛的免疫抑制作用，但这会增加感染风险并减弱疫苗引发的免疫力.更有针对性的方法是以自身抗原特异性方式重新建立免疫耐受性。这篇综述讨论了实现这一目标的方法，专注于耐受性树突状细胞。其他自身免疫性疾病的临床试验也提供了关于这种方法的临床翻译的学习。包括自身抗原的鉴定，选择合适的患者以及给药途径和频率。
