蠕虫病,影响全球数十亿人,构成了重大的健康问题,特别是在卫生条件不足的贫困地区。蠕虫复杂的解剖复杂性需要专门的治疗方法。目前没有针对蠕虫感染的有效疫苗。驱虫药,对于对抗这些感染至关重要,在不伤害宿主的情况下,针对寄生虫的神经肌肉功能。然而,对现有驱虫药的抗性的出现,特别是苯并咪唑,提出了日益增长的全球挑战。这篇综述深入研究了先前合成的核心驱虫支架-苯并咪唑的结构-活性关系,香豆素,吡唑啉,三唑,和其他人-阐明他们有希望的驱虫活动。了解这些新型苯并咪唑衍生物的结构-活性关系,香豆素衍生物,其他人对设计有效的驱虫药至关重要,克服阻力,并优化疗效以对抗不断升级的全球蠕虫感染负担。在本次审查中,我们涵盖了最近研究的化合物(从2019年到目前为止),这些化合物具有有希望的驱虫活性。这篇综述将有助于药理学和药物化学研究人员在该领域使用各种支架,如氨基苯并噻唑,苯并咪唑,苯并噻唑,香豆素,色烯,螺缩酮,吡唑啉,三唑,等。设计新型有效的驱虫化合物。
Helminthiasis, affecting billions globally, poses a significant health concern, especially in impoverished regions with inadequate sanitation. The intricate anatomical complexity of helminths requires specialized treatment approaches. There is currently no effective vaccine against helminth infections. Anthelmintics, crucial for combating these infections, target neuromuscular functions in parasites without harming the host. However, the emergence of resistance to existing anthelmintics, notably benzimidazoles, presents a growing global challenge. This review delves into the structure-activity relationship of previously synthesized core
anthelmintic scaffolds-Benzimidazole, coumarin, pyrazoline, triazole, and others-to elucidate their promising
anthelmintic activities. Understanding the structure-activity relationship of these novel benzimidazole derivatives, Coumarin derivatives, and others is crucial in designing potent anthelmintics, overcoming resistance, and optimizing efficacy to combat the escalating global burden of helminth infections. In the present review, we cover recently studied compounds (from the year 2019 to till date) which have promising
anthelmintic activity. This review will be useful for the pharmacology and medicinal chemistry researchers working in the area anthelmintics with various scaffolds like aminobenzothiazole, benzimidazole, benzothiazole, coumarin, chromene, spiroketal, pyrazoline, triazole, etc. to design novel potent
anthelmintic compound.