{Reference Type}: Journal Article
{Title}: Antiparasitic activity of the steroid-rich extract of Schima wallichii against poultry cestode.
{Author}: Lalthanpuii PB;Lalchhandama K;
{Journal}: Vet World
{Volume}: 17
{Issue}: 6
{Year}: 2024 Jun
暂无{DOI}: 10.14202/vetworld.2024.1299-1306
{Abstract}: <B>UNASSIGNED: </B>Schima wallichii Korth., commonly known as the needlewood tree (family Theaceae) has therapeutic uses in traditional Mizo medicine for human helminthiasis and serves as a balm against ectoparasites in animals. Although the medicinal properties have been studied experimentally, its use as a traditional anthelmintic remains unexplored. This study aimed to analyze the chemical components and antiparasitic activity of S. wallichii.<BR><B>UNASSIGNED: </B>The chemical analysis of S. wallichi bark extracts was conducted focusing on the secondary metabolites using petroleum ether, chloroform, and methanol. Gas chromatography-mass spectrometry (GC-MS) was used to identify the specific compounds. An anthelmintic susceptibility test was carried out against Raillietina tetragona, intestinal cestode parasite of fowl.<BR><B>UNASSIGNED: </B>The methanol extract yielded the highest concentrations of alkaloids, carbohydrates, glycosides, sterols, saponins, and tannins among all the extracts. Sterols were the most abundant compounds in all extracts, with flavonoids being absent. Secondary metabolites were largely absent in the petroleum ether and chloroform extracts. The GC-MS data identified cholest-22-ene-21-ol as the major steroid component. The cestode parasite was inhibited in a concentration-dependent manner by the plant extract. The plant extract's anthelmintic activity was evident through observable damage to the parasite's outer structure.<BR><B>UNASSIGNED: </B>Phytosterols in S. wallichii bark are responsible for its anthelmintic properties. The mechanism and pharmaceutical properties of the anthelmintic molecule require further exploration.