PDF(Pubmed)
Abstract：
UNASSIGNED: Schima wallichii Korth., commonly known as the needlewood tree (family Theaceae) has therapeutic uses in traditional Mizo medicine for human helminthiasis and serves as a balm against ectoparasites in animals. Although the medicinal properties have been studied experimentally, its use as a traditional anthelmintic remains unexplored. This study aimed to analyze the chemical components and antiparasitic activity of S. wallichii.
UNASSIGNED: The chemical analysis of S. wallichi bark extracts was conducted focusing on the secondary metabolites using petroleum ether, chloroform, and methanol. Gas chromatography-mass spectrometry (GC-MS) was used to identify the specific compounds. An anthelmintic susceptibility test was carried out against Raillietina tetragona, intestinal cestode parasite of fowl.
UNASSIGNED: The methanol extract yielded the highest concentrations of alkaloids, carbohydrates, glycosides, sterols, saponins, and tannins among all the extracts. Sterols were the most abundant compounds in all extracts, with flavonoids being absent. Secondary metabolites were largely absent in the petroleum ether and chloroform extracts. The GC-MS data identified cholest-22-ene-21-ol as the major steroid component. The cestode parasite was inhibited in a concentration-dependent manner by the plant extract. The plant extract\'s anthelmintic activity was evident through observable damage to the parasite\'s outer structure.
UNASSIGNED: Phytosterols in S. wallichii bark are responsible for its anthelmintic properties. The mechanism and pharmaceutical properties of the anthelmintic molecule require further exploration.
UNASSIGNED: The chemical analysis of S. wallichi bark extracts was conducted focusing on the secondary metabolites using petroleum ether, chloroform, and methanol. Gas chromatography-mass spectrometry (GC-MS) was used to identify the specific compounds. An anthelmintic susceptibility test was carried out against Raillietina tetragona, intestinal cestode parasite of fowl.
UNASSIGNED: The methanol extract yielded the highest concentrations of alkaloids, carbohydrates, glycosides, sterols, saponins, and tannins among all the extracts. Sterols were the most abundant compounds in all extracts, with flavonoids being absent. Secondary metabolites were largely absent in the petroleum ether and chloroform extracts. The GC-MS data identified cholest-22-ene-21-ol as the major steroid component. The cestode parasite was inhibited in a concentration-dependent manner by the plant extract. The plant extract\'s anthelmintic activity was evident through observable damage to the parasite\'s outer structure.
UNASSIGNED: Phytosterols in S. wallichii bark are responsible for its anthelmintic properties. The mechanism and pharmaceutical properties of the anthelmintic molecule require further exploration.
摘要：
■千马华立木科思。,通常被称为针木树（Theaceae家族），在传统的Mizo药物中用于治疗人类蠕虫病，并可作为动物体外寄生虫的香脂。尽管已经通过实验研究了药用特性，它作为传统驱虫药的使用仍未被探索。本研究旨在分析华木的化学成分和抗寄生虫活性。
■使用石油醚对S.wallichi树皮提取物进行了化学分析，重点研究了次级代谢产物，氯仿,和甲醇。气相色谱-质谱(GC-MS)用于鉴定特定化合物。对四角雷利替纳进行了驱虫敏感性试验，鸡的肠道寄生虫。
■甲醇提取物产生的生物碱浓度最高，碳水化合物,糖苷，固醇,皂苷,和所有提取物中的单宁。甾醇是所有提取物中最丰富的化合物，没有黄酮类化合物。石油醚和氯仿提取物中基本上不存在次生代谢产物。GC-MS数据确定了胆盐-22-烯-21-醇是主要的类固醇成分。植物提取物以浓度依赖的方式抑制了c虫寄生虫。植物提取物的驱虫活性通过对寄生虫的外部结构的可观察到的损害而明显。
■水木树皮中的植物甾醇是其驱虫特性的原因。驱虫分子的机制和药物特性需要进一步探索。
■使用石油醚对S.wallichi树皮提取物进行了化学分析，重点研究了次级代谢产物，氯仿,和甲醇。气相色谱-质谱(GC-MS)用于鉴定特定化合物。对四角雷利替纳进行了驱虫敏感性试验，鸡的肠道寄生虫。
■甲醇提取物产生的生物碱浓度最高，碳水化合物,糖苷，固醇,皂苷,和所有提取物中的单宁。甾醇是所有提取物中最丰富的化合物，没有黄酮类化合物。石油醚和氯仿提取物中基本上不存在次生代谢产物。GC-MS数据确定了胆盐-22-烯-21-醇是主要的类固醇成分。植物提取物以浓度依赖的方式抑制了c虫寄生虫。植物提取物的驱虫活性通过对寄生虫的外部结构的可观察到的损害而明显。
■水木树皮中的植物甾醇是其驱虫特性的原因。驱虫分子的机制和药物特性需要进一步探索。
