传统的伤口闭合方法,包括缝合线和组织粘合剂,对自我护理治疗提出了重大挑战,特别是在伤口出血的情况下。设计用于自主伤口闭合的现有刺激响应性收缩材料经常缺乏足够的输出功密度来产生使伤口边缘接近或需要与人体不相容的刺激所需的力。这里,我们报告的是半透明的,灵活,和水响应收缩薄膜,由聚环氧乙烷和α-环糊精组成。这些薄膜在环境条件下表现出显著的稳定性,并在暴露于水中的6秒内表现出显著的收缩(~50%),产生大量的收缩应力(高达6兆帕)和输出功密度(~1028kJm-3),比传统水凝胶大100倍,比骨骼肌大25倍。值得注意的是,水合后,这些薄膜能够举起自身重量的10000倍的物体。利用这项技术,我们进一步开发了水收缩带,which,与水接触时,在10秒内有效收缩人类皮肤和自主闭合动物模型中的出血伤口。我们的工作提供了一种新颖的皮肤伤口管理方法,显示出紧急和自我护理场景的巨大潜力。本文受版权保护。保留所有权利。
Conventional wound closure methods, including sutures and tissue adhesives, present significant challenges for self-care treatment, particularly in the context of bleeding wounds. Existing stimuli-responsive contractile materials designed for autonomous wound closure frequently lack sufficient output work density to generate the force needed to bring the wound edges into proximity or necessitate stimuli that are not compatible with the human body. Here, semi-transparent, flexible, and water-responsive shrinkable films, composed of poly(ethylene oxide) and α-cyclodextrin, are reported. These films exhibit remarkable stability under ambient conditions and demonstrate significant contraction (≈50%) within 6 s upon exposure to water, generating substantial contractile stress (up to 6 MPa) and output work density (≈1028 kJ m-3), which is 100 times larger than that of conventional hydrogel and 25 times larger than that of skeletal muscles. Remarkably, upon hydration, these films are capable of lifting objects 10 000 times their own weight. Leveraging this technology, water-shrink tapes, which, upon contact with water, effectively constrict human skin and autonomously close bleeding wounds in animal models within 10 seconds, are developed further. This work offers a novel approach to skin wound management, showing significant potential for emergency and self-care scenarios.