一种先前未描述的双拉布丹二萜，即非洲莫莫拉布丹(1)，与七种已知化合物（2-8）一起从紫草种子中分离得到。它们的结构是基于HR-ESI-MS的综合分析建立的，结合他们的1D和2D-NMR数据。评价化合物1对四种癌细胞系:A549、HepG2、SPC212和DLD-1的细胞毒活性。对SPC212肺癌细胞系观察到最佳活性,IC50值为0.52μM。
A previously undescribed bislabdane diterpenoid namely
aframomumlabdane (1), was isolated from the seed of Aframomum arundinaceum together with seven known compounds (2 - 8). Their structures were established based on a comprehensive analysis of HR-ESI-MS, in conjunction with their 1D and 2D-NMR data. Compound 1 was evaluated for its cytotoxic activity against four cancer cell lines: A549, HepG2, SPC212 and DLD-1. The best activity was observed against SPC212 lung cancer cell line with an IC50 value of 0.52 μM.
