本研究旨在探讨12周有氧运动(AT)和补充藏红花对止血效果的影响,炎症标志物,肥胖女性诊断为2型糖尿病(T2D)的胰岛素抵抗。共有44名女性患有T2D(平均年龄:54.12±5.63岁,平均BMI:31.15±1.50kg/m2,HbA1c:85±4.2mmol/mol)纳入随机研究,双盲,安慰剂对照研究。我们被随机分配到四组中的一组(每组n=11):藏红花训练(ST),安慰剂+训练(PT),藏红花补充剂(SS),和安慰剂(P)。ST和PT组完成了12周的AT(每周三次轻度至中度强度)。ST组和SS组每天服用200mg藏红花粉,持续12周。在第一次AT会话和/或营养补充之前48小时和最后一次AT会话和/或营养补充之后48小时收集空腹血液样品。后评价,胰岛素抵抗值的稳态模型评估(HOMA-IR,p<0.001)和血清葡萄糖水平(p<0.001),纤维蛋白原(FIB,p<0.001),同型半胱氨酸(HCY,p<0.001),白细胞介素-6(IL-6,p<0.001),和肿瘤坏死因子α(TNFα,p<0.001)显示ST显著降低,PT,而SS组与P组比拟(p<0.05)。特别是,与PT和SS组相比,ST组所有变量均显著降低(p<0.05).我们的结果表明,12周的AT和藏红花补充干预可以独立地改善与止血相关的标志物,炎症,和胰岛素抵抗。然而,它们的组合在上述标记上显示出最大的有效性。
This study was conducted to investigate the effects of 12 weeks of aerobic exercise (AT) and saffron supplementation on hemostasis, inflammatory markers, and insulin resistance in obese women diagnosed with type 2 diabetes (T2D). A total of 44 women with T2D (mean age: 54.12 ± 5.63 years, mean BMI: 31.15 ± 1.50 kg/m2, HbA1c: 85 ± 4.2 mmol/mol) were included in a randomized, double-blind, placebo-controlled study. We were randomly assigned to one of four groups (n = 11 per group): saffron + training (ST), placebo + training (PT), saffron supplement (SS), and placebo (P). The ST and PT groups completed 12 weeks of AT (three sessions per week of mild to moderate intensity). The ST and SS groups were administered a daily dose of 200 mg of saffron powder for 12 weeks. Fasting blood samples were collected 48 h before the first AT session and/or nutritional supplementation and 48 h after the last AT session and/or nutritional supplementation. Post-evaluation, homeostatic model assessment of insulin resistance value (HOMA-IR, p < 0.001) and serum levels of glucose (p < 0.001), fibrinogen (FIB, p < 0.001), homocysteine (HCY, p < 0.001), interleukin-6 (IL-6, p < 0.001), and tumor necrosis factor α (TNFα, p < 0.001) showed significant reduction in the ST, PT, and SS groups compared to the P group (p < 0.05). In particular, the ST group showed a more significant reduction in all variables compared to the PT and SS groups (p < 0.05). Our results suggest that a 12-week intervention with AT and saffron supplementation can independently improve markers related to hemostasis, inflammation, and insulin resistance. However, their combination showed the greatest effectiveness on the above markers.