PDF(Pubmed)
Abstract：
Several genetic markers have shown associations with muscle performance and physical abilities, but the response to exercise therapy is still unknown. The aim of this study was to test the response of patients with long COVID through an aerobic physical therapy strategy by the Nordic walking program and how several genetic polymorphisms involved in muscle performance influence physical capabilities. Using a nonrandomized controlled pilot study, 29 patients who previously suffered from COVID-19 (long COVID = 13, COVID-19 = 16) performed a Nordic walking exercise therapy program for 12 sessions. The influence of the ACE (rs4646994), ACTN3 (rs1815739), AMPD1 (rs17602729), CKM (rs8111989), and MLCK (rs2849757 and rs2700352) polymorphisms, genotyped by using single nucleotide primer extension (SNPE) in lactic acid concentration was established with a three-way ANOVA (group × genotype × sessions). For ACE polymorphism, the main effect was lactic acid (p = 0.019). In ACTN3 polymorphism, there were no main effects of lactic acid, group, or genotype. However, the posthoc analysis revealed that, in comparison with nonlong COVID, long COVID increased lactic acid concentrations in Nordic walking sessions in CT and TT genotypes (all p < 0.05). For AMPD1 polymorphism, there were main effects of lactic acid, group, or genotype and lactic acid × genotype or lactic acid × group × genotype interactions (all p < 0.05). The posthoc analysis revealed that, in comparison with nonlong COVID, long COVID increased lactic acid concentrations in Nordic walking sessions in CC and CT genotypes (all p < 0.05). Physical therapy strategy through Nordic walking enhanced physical capabilities during aerobic exercise in post-COVID19 patients with different genotypes in ACTN3 c.1729C>T and AMPD1 c.34C>T polymorphisms. These findings suggest that individuals who reported long COVID who presumably exercised less beforehand appeared to be less able to exercise, based on lactate levels, and the effect of aerobic physical exercise enhanced physical capabilities conditioned by several genetic markers in long COVID patients.
摘要：
一些遗传标记已经显示出与肌肉性能和身体能力有关，但是对运动疗法的反应仍然未知。这项研究的目的是通过北欧步行计划通过有氧物理治疗策略测试长期COVID患者的反应，以及肌肉表现中涉及的几种遗传多态性如何影响身体能力。使用非随机对照试验研究，29名先前患有COVID-19（长COVID=13，COVID-19=16）的患者进行了为期12个疗程的北欧步行运动疗法。ACE的影响（rs4646994），ACTN3(rs1815739),AMPD1(rs17602729),CKM(rs8111989),和MLCK(rs2849757和rs2700352)多态性，通过使用乳酸浓度的单核苷酸引物延伸（SNPE）进行基因分型，采用三因素方差分析（组×基因型×会话）。对于ACE多态性，主要效应为乳酸(p=0.019)。在ACTN3多态性中，没有乳酸的主要作用，group,或基因型。然而,posthoc分析显示，与非长COVID相比，长COVID增加了CT和TT基因型北欧步行会话中的乳酸浓度（均p<0.05）。对于AMPD1多态性，有乳酸的主要作用，group,或基因型与乳酸×基因型或乳酸×组×基因型相互作用(均p<0.05)。posthoc分析显示，与非长COVID相比，长期COVID增加了CC和CT基因型北欧步行中的乳酸浓度（均p<0.05）。通过北欧步行的物理治疗策略增强了ACTN3c.1729C>T和AMPD1c.34C>T多态性不同基因型的COVID19患者有氧运动期间的身体能力。这些发现表明，报告长期COVID的人可能事先锻炼较少的人似乎锻炼能力较差，根据乳酸水平，有氧体育锻炼的作用增强了长期COVID患者的几种遗传标记的身体能力。
