许多癌症表现出全染色体不稳定性（W-CIN）和结构染色体不稳定性（S-CIN）。指的是获得数字和结构异常染色体变化的速率增加。该协议提供了详细的步骤来分析跨癌症类型的W-CIN和S-CIN，打算利用大规模批量测序和SNP阵列数据补充计算模型，以更好地了解W-CIN和S-CIN。
Many cancers display whole chromosome instability (W-CIN) and structural chromosomal instability (S-CIN), referring to increased rates of acquiring numerically and structurally abnormal chromosome changes. This protocol provides detailed steps to analyze the W-CIN and S-CIN across cancer types, intending to leverage large-scale bulk sequencing and SNP array data complemented with the computational models to gain a better understanding of W-CIN and S-CIN.
