%0 Journal Article
%T Profiling Numerical and Structural Chromosomal Instability in Different Cancer Types.
%A Zhang X
%A Kschischo M
%J Methods Mol Biol
%V 2825
%N 0
%D 2024
%M 38913320
暂无%R 10.1007/978-1-0716-3946-7_20
%X Many cancers display whole chromosome instability (W-CIN) and structural chromosomal instability (S-CIN), referring to increased rates of acquiring numerically and structurally abnormal chromosome changes. This protocol provides detailed steps to analyze the W-CIN and S-CIN across cancer types, intending to leverage large-scale bulk sequencing and SNP array data complemented with the computational models to gain a better understanding of W-CIN and S-CIN.