未经证实:肥胖和心脏代谢功能障碍与癌症风险和严重程度相关。潜在机制仍不清楚。
UNASSIGNED:本研究的目的是研究肥胖和相关心脏代谢特征与癌症发病的关系。
UNASHSIGNED:FHS(弗雷明汉心脏研究)和PREVEND(预防肾脏和血管终末期疾病)研究参与者没有普遍癌症,检查肥胖的关联,体重指数(BMI),腰围,内脏脂肪组织(VAT)和皮下脂肪组织仓库,和C反应蛋白(CRP)与Cox模型中的未来癌症。
未经评估:在20,667名参与者中(平均年龄50岁,53%的妇女),在15年的中位随访时间内观察到2,619例癌症事件。肥胖与未来胃肠道风险增加相关(HR:1.30;95%CI:1.05-1.60),妇科(HR:1.62;95%CI:1.08-2.45),和乳腺癌(HR:1.32;95%CI:1.05-1.66)和肺癌的风险较低(HR:0.62;95%CI:0.44-0.87)。同样,腰围与总体风险增加相关,胃肠,和妇科但不是肺癌。增值税而非皮下脂肪组织与整体癌症风险相关(HR:1.22;95%CI:1.05-1.43),肺癌(HR:1.92;95%CI:1.01-3.66),和黑色素瘤(HR:1.56;95%CI:1.02-2.38)与BMI无关。最后,较高的CRP水平与较高的总体风险相关,结直肠,肺癌(均P<0.05)。
未经证实:肥胖和腹部肥胖与未来患特定癌症的风险有关(例如,胃肠,妇科)。尽管肥胖与肺癌风险较低有关,调整BMI后,较高的VAT和CRP与较高的肺癌风险相关.
UNASSIGNED: Obesity and cardiometabolic dysfunction have been associated with cancer risk and severity. Underlying mechanisms remain unclear.
UNASSIGNED: The aim of this study was to examine associations of obesity and related cardiometabolic traits with incident cancer.
UNASSIGNED: FHS (Framingham Heart Study) and PREVEND (Prevention of Renal and Vascular End-Stage Disease) study participants without prevalent cancer were studied, examining associations of obesity, body mass index (BMI), waist circumference, visceral adipose tissue (VAT) and subcutaneous adipose tissue depots, and C-reactive protein (CRP) with future cancer in Cox models.
UNASSIGNED: Among 20,667 participants (mean age 50 years, 53% women), 2,619 cancer events were observed over a median follow-up duration of 15 years. Obesity was associated with increased risk for future gastrointestinal (HR: 1.30; 95% CI: 1.05-1.60), gynecologic (HR: 1.62; 95% CI: 1.08-2.45), and breast (HR: 1.32; 95% CI: 1.05-1.66) cancer and lower risk for lung cancer (HR: 0.62; 95% CI: 0.44-0.87). Similarly, waist circumference was associated with increased risk for overall, gastrointestinal, and gynecologic but not lung cancer. VAT but not subcutaneous adipose tissue was associated with risk for overall cancer (HR: 1.22; 95% CI: 1.05-1.43), lung cancer (HR: 1.92; 95% CI: 1.01-3.66), and melanoma (HR: 1.56; 95% CI: 1.02-2.38) independent of BMI. Last, higher CRP levels were associated with higher risk for overall, colorectal, and lung cancer (P < 0.05 for all).
UNASSIGNED: Obesity and abdominal adiposity are associated with future risk for specific cancers (eg, gastrointestinal, gynecologic). Although obesity was associated with lower risk for lung cancer, greater VAT and CRP were associated with higher lung cancer risk after adjusting for BMI.