背景:高海拔暴露会改变心脏的电传导。然而,关于高原适应和非适应期间的心电图(ECG)特征和有效的预防剂的报告不足。本研究旨在探讨泛醇对高原缺氧复氧后电生理的影响。
方法:这项研究是一项前瞻性的,随机化,双盲,安慰剂对照试验。41名参与者被随机分为两组,在飞往高海拔(3900m)直到研究结束前14天,每天接受200mg的泛醇或口服安慰剂。在基线(300m)进行心肺运动测试,到达高海拔后的第三天,回到基线后的第七天。
结果:急性高原暴露延长静息心室复极,以增加的校正QT间期(455.9±23.4vs.427.1±19.1ms,P<0.001)和校正的Tpeak-Tend间隔(155.5±27.4vs.125.3±21.1ms,P<0.001),返回低海拔后恢复。补充泛醇缩短了低氧诱导的延长的Tpeak-Tend间隔(-7.7ms,[95%置信区间(CI),-13.8至-1.6],P=0.014),Tpeak-Tend/QT间期(-0.014[95%CI,-0.027至-0.002],P=0.028),和保留的最大心率(11.9bpm[95%CI,3.2至20.6],在高海拔运动期间P=0.013)。此外,V3导联ST段静息幅度降低与峰值氧脉搏降低(R=0.713,P<0.001)和最大耗氧量(R=0.595,P<0.001)相关。
结论:我们的结果说明了高原适应和去适应过程中的电生理变化。同样,在高海拔地区运动期间,补充泛醇会缩短延长的Tpeak-Tend间隔并保留最大心率。
背景:URL:www.chictr.org.cn;唯一标识符:ChiCTR2200059900。
BACKGROUND: High-altitude exposure changes the electrical conduction of the heart. However, reports on electrocardiogram (ECG) characteristics and potent prophylactic agents during high-altitude acclimatization and de-acclimatization are inadequate. This study aimed to investigate the effects of
ubiquinol on electrophysiology after high-altitude hypoxia and reoxygenation.
METHODS: The study was a prospective, randomized, double-blind, placebo-controlled trial. Forty-one participants were randomly divided into two groups receiving
ubiquinol 200 mg daily or placebo orally 14 days before flying to high altitude (3900 m) until the end of the study. Cardiopulmonary exercise testing was performed at baseline (300 m), on the third day after reaching high altitude, and on the seventh day after returning to baseline.
RESULTS: Acute high-altitude exposure prolonged resting ventricular repolarization, represented by increased corrected QT interval (455.9 ± 23.4 vs. 427.1 ± 19.1 ms, P < 0.001) and corrected Tpeak-Tend interval (155.5 ± 27.4 vs. 125.3 ± 21.1 ms, P < 0.001), which recovered after returning to low altitude.
Ubiquinol supplementation shortened the hypoxia-induced extended Tpeak-Tend interval (-7.7 ms, [95% confidence interval (CI), -13.8 to -1.6], P = 0.014), Tpeak-Tend /QT interval (-0.014 [95% CI, -0.027 to -0.002], P = 0.028), and reserved maximal heart rate (11.9 bpm [95% CI, 3.2 to 20.6], P = 0.013) during exercise at high altitude. Furthermore, the decreased resting amplitude of the ST-segment in the V3 lead was correlated with decreased peak oxygen pulse (R = 0.713, P < 0.001) and maximum oxygen consumption (R = 0.595, P < 0.001).
CONCLUSIONS: Our results illustrated the electrophysiology changes during high-altitude acclimatization and de-acclimatization. Similarly,
ubiquinol supplementation shortened the prolonged Tpeak-Tend interval and reserved maximal heart rate during exercise at high altitude.
BACKGROUND: URL: www.chictr.org.cn; Unique identifier: ChiCTR2200059900.