PDF(Pubmed)
Abstract：
Aim: We aim to analyze past literature to evaluate the efficacy of coenzyme Q10 (CoQ-10) in the population with heart failure (HF). Methods: A systematic literature search was conducted through MEDLINE (via PubMed) and Cochrane Library. The outcomes analyzed were a reduction in HF-related mortality, an improvement in exercise capacity, and the left ventricular ejection fraction (LVEF). Results: Among 16 studies, CoQ-10 significantly reduced HF-related mortality by 40% and improved exercise capacity in patients with HF, but demonstrated no significant difference in LVEF however, the potential of its efficacy on LVEF could not be ruled out. Conclusion: CoQ-10 significantly enhances exercise capacity and reduces HF-related mortality; however, its impact on patients with reduced LVEF requires further investigation.
[Box: see text].
[Box: see text].
摘要：
目的：我们旨在分析过去的文献，以评估辅酶Q10（CoQ-10）在心力衰竭（HF）人群中的疗效。方法：通过MEDLINE（通过PubMed）和Cochrane图书馆进行系统的文献检索。分析的结果是HF相关死亡率的降低，锻炼能力的提高，左心室射血分数(LVEF)。结果：在16项研究中，CoQ-10可显著降低HF相关死亡率40%，改善HF患者的运动能力，但显示LVEF没有显着差异，不能排除其对LVEF的潜在疗效.结论：CoQ-10能显著增强运动能力，降低HF相关死亡率；然而，其对LVEF降低患者的影响需要进一步研究.
[方框：见正文]。
[方框：见正文]。
