PDF(Pubmed)
Abstract：
Coenzyme Q10 (CoQ10) plays a key role in many aspects of cellular metabolism. For CoQ10 to function normally, continual interconversion between its oxidised (ubiquinone) and reduced (ubiquinol) forms is required. Given the central importance of this ubiquinone-ubiquinol redox cycle, this article reviews what is currently known about this process and the implications for clinical practice. In mitochondria, ubiquinone is reduced to ubiquinol by Complex I or II, Complex III (the Q cycle) re-oxidises ubiquinol to ubiquinone, and extra-mitochondrial oxidoreductase enzymes participate in the ubiquinone-ubiquinol redox cycle. In clinical terms, the outcome of deficiencies in various components associated with the ubiquinone-ubiquinol redox cycle is reviewed, with a particular focus on the potential clinical benefits of CoQ10 and selenium co-supplementation.
摘要：
辅酶Q10（CoQ10）在细胞代谢的许多方面起着关键作用。为了使CoQ10正常运行，需要其氧化（泛醌）和还原（泛醇）形式之间的连续相互转化。鉴于泛醌-泛醇氧化还原循环的重要性，本文回顾了目前对这一过程的了解以及对临床实践的启示。在线粒体中，泛醌被络合物I或II还原成泛醇，复合物III（Q循环）将泛醌重新氧化为泛醌，线粒体外氧化还原酶参与泛醌-泛醇氧化还原循环。在临床上,对与泛醌-泛醇氧化还原循环相关的各种成分缺乏的结果进行了综述，特别关注辅酶Q10和硒联合补充的潜在临床益处。
