■先前的研究表明,不适当的童年养育经历(低照顾和高过度保护),特质焦虑,抑郁沉思是抑郁症的危险因素。然而,迄今为止,尚无研究分析这些因素与抑郁症状之间的总体关联.在本研究中,我们假设抑郁沉思可以介导不适当的童年养育经历对抑郁症状的影响,这些中介效应是由特质焦虑调节的,并在成年志愿者身上测试了这些假设。
■受试者是在2017年4月至2018年4月期间接受调查的成年志愿者。关于人口统计数据的自我报告问卷,童年的养育经历,特质焦虑,抑郁沉思,并分发了抑郁症状进行调查,从585名受试者中获得书面知情同意书和有效应答.通过SPSS28和宏PROCESS4.0软件进行调解和适度调解分析。本研究获得了东京医科大学伦理委员会的批准。
■父母护理通过其对抑郁反思性的影响对抑郁症状显示出显着的负面间接影响(p<0.01),而父母过度保护表现出相反的效果(p<0.01)。此外,特质焦虑增强了抑郁反思性对抑郁症状的中介作用(p<0.05)。
■我们目前的研究表明,影响抑郁症状的主要因素是不适当的童年养育经历,通过加剧抑郁沉思间接增强抑郁,抑郁沉思和特质焦虑相互促进,增强抑郁症状。这些发现可能对预防抑郁症状有用。未来需要大规模的前瞻性研究来确认这些因素之间的因果关系。
UNASSIGNED: Prior research has shown that inappropriate childhood nurturing experiences (low care and high overprotection), trait anxiety, and depressive rumination are risk factors for depression. However, no studies to date have analyzed the overall association between these factors and depressive symptoms. In the present study, we hypothesized that depressive rumination mediates the impacts of inappropriate childhood nurturing experiences on depressive symptoms, and that these mediating effects are moderated by trait anxiety, and tested these hypotheses in adult volunteers.
UNASSIGNED: The subjects were adult volunteers who were investigated between April 2017 and April 2018. A self-report questionnaire on demographic data, childhood nurturing experiences, trait anxiety, depressive rumination, and depressive symptoms was distributed to conduct the survey, and written informed consent and valid responses were obtained from 585 subjects. Mediation and moderated-mediation analyses were performed by SPSS 28 and macro PROCESS 4.0 software. This study was approved by the Ethics Committee of Tokyo Medical University.
UNASSIGNED: Parental care showed a significant negative indirect effect on depressive symptoms via its effect on depressive rumination (p < 0.01), whereas parental overprotection showed the opposite effect (p < 0.01). Furthermore, the mediation effect of depressive rumination on depressive symptoms was increased by trait anxiety (p < 0.05).
UNASSIGNED: Our present study demonstrated that the main factor affecting depressive symptoms is inappropriate childhood nurturing experiences, which indirectly enhance depression by intensifying depressive rumination, and that depressive rumination and trait anxiety mutually reinforce each other to enhance depressive symptoms. These findings may be useful for the prevention of depressive symptoms. Large-scale prospective studies are needed to confirm the causal associations among these factors in the future.