背景:外用胰岛素可促进和加速角膜再生,即使在有严重合并症的眼睛里,与其他治疗方案相比,提供了一些好处。
目的:本研究的目的是评估局部胰岛素治疗复发性上皮性角膜糜烂的效果。
方法:将复发性上皮糜烂患者纳入一项前瞻性非随机医院研究,分成两组,其中一人接受持续性上皮缺损(PEDs)常规治疗,另一人接受相同的胰岛素滴眼液治疗4次/天.所有患者均用裂隙灯仔细检查。患者在1号,2nd,3rd,第4周以及2个月后。人口统计,病因学,治疗,合并症,进行PED的愈合时间。
结果:2周后面积显着改善(p=0.006),2个月(p=0.046),与第I组(Cornetears凝胶和局部胰岛素)相比,第II组(Cornetears凝胶和局部胰岛素)为3个月(p=0.002)。Cornetears凝胶和局部胰岛素(II组)的复发率降低了0.0%,具有统计学意义。与Cornetears凝胶(I组)相比,有3例患者(21.4%)。
结论:局部胰岛素可促进复发性上皮糜烂的角膜上皮再生,并减少这些病例的复发。其他优点包括出色的耐受性,可用性,和成本效益。
BACKGROUND: Topical insulin can promote and accelerate corneal regeneration, even in eyes with serious comorbidities, and offers several benefits over other treatment options.
OBJECTIVE: The aim of this study is to evaluate the effect of topical insulin in treatment of recurrent epithelial corneal erosion.
METHODS: Patients with recurrent epithelial erosions were included in a prospective non-randomized hospital-based study, divided into two groups, one of them received persistent epithelial defects (PEDs) conventional treatment and the other received the same treatment with insulin eye drops 4 times/day. All patients were examined carefully by slit lamp. Patients during the 1st, 2nd, 3rd, and 4th weeks as well as after 2 months. Demographics, etiology, therapy, comorbidities, and the healing time of PED were performed.
RESULTS: Area shows significant improvement after 2 weeks (p = 0.006), 2 months (p = 0.046), and 3 months (p = 0.002) in group II (cornetears gel and topical insulin) as compared to group I (cornetears gel). The recurrence was statistically significant decreased with cornetears gel and topical insulin (group II) by 0.0%, as compared to cornetears gel (group I) by 3 patients (21.4%).
CONCLUSIONS: Topical insulin can promote corneal reepithelization in recurrent epithelial erosion and decreases recurrence in these cases. Other advantages include excellent tolerance, availability, and cost-effectiveness.