Abstract：
Corneal epithelial defects are one of the most common ocular disorders. Restoring corneal integrity is crucial to reduce pain and regain function, but in cases of neurotrophic or desensitized corneas, healing can be significantly delayed. Treating neurotrophic corneas is challenging for ophthalmologists, and surgical intervention is often indicated to manage refractory cases that are unresponsive to medical therapy. Over the last decade, as more expensive therapeutics reach the market, topical insulin has returned to the forefront as an affordable option to improve corneal wound healing. There is still a paucity of data on the use and the efficacy of topical insulin, with no consensus regarding its indications, preparation, or posology. Here we review the literature on topical insulin for corneal and ocular surface pathologies, with a focus on the current evidence, its mechanisms of action, and its safety profile. Additionally, we share our experience in the field and provide a potential framework for future research.
摘要：
角膜上皮缺损是最常见的眼部疾病之一。恢复角膜完整性对于减轻疼痛和恢复功能至关重要。但是在神经营养或脱敏角膜的情况下，愈合可能会明显延迟。治疗神经营养性角膜对眼科医生来说是具有挑战性的，手术干预通常用于治疗对药物治疗无反应的难治性病例。在过去的十年里，随着更昂贵的疗法进入市场，局部胰岛素作为改善角膜伤口愈合的一种可负担的选择已回到前列.关于局部胰岛素的使用和疗效的数据仍然很少，在对其适应症没有共识的情况下，准备,或posology。在这里，我们回顾了局部胰岛素用于角膜和眼表病理的文献，专注于当前的证据，其作用机制,和它的安全概况。此外,我们分享我们在该领域的经验，并为未来的研究提供一个潜在的框架。
