Topical Insulin in Neurotrophic Keratopathy: A Review of Current Understanding of the Mechanism of Action and Therapeutic Approach.

局部胰岛素在神经营养性角膜病变中的作用机制和治疗方法的最新认识。

• 影响指数: 6.525
• 发表时间: 2023 Dec 20
• 来源期刊: Pharmaceutics
• DOI: 10.3390/pharmaceutics16010015
• PMID: 38276493
• 文章类型: Journal Article
• 中科院分区: Q3
• 方向: 医学
• 作者列表: Jaworski M,Lorenc A,Leszczyński R,Mrukwa-Kominek E

关键词: corneal insulin receptors; corneal ulcer; eye disease; neurotrophic keratopathy; topical insulin

Abstract

Neurotrophic keratopathy is a corneal disease characterized by impaired corneal innervation. It can lead to corneal epithelial defects, ulcerations, and perforations. Topical insulin has been shown to be effective in treating this disorder. Insulin is a growth factor that can promote corneal epithelial cell proliferation and migration. In addition, it can also inhibit corneal epithelial cell apoptosis. Topical insulin has previously been found to enhance corneal wound healing. This article reviews the current understanding of the mechanism of action of topical insulin in the treatment of neurotrophic keratopathy.

摘要

神经营养性角膜病变是一种以角膜神经支配受损为特征的角膜疾病。会导致角膜上皮缺损,溃疡,和穿孔。已证明局部胰岛素可有效治疗这种疾病。胰岛素是一种能促进角膜上皮细胞增殖和迁移的生长因子。此外,还能抑制角膜上皮细胞凋亡。先前已发现局部胰岛素可增强角膜伤口愈合。本文综述了目前对局部胰岛素治疗神经营养性角膜病变的作用机制的认识。