■腹膜胶质瘤病(GP)是一种罕见的实体,其特征是多个成熟的神经胶质组织植入物与腹膜和网膜中的卵巢畸胎瘤有关。迄今为止,仅发表了100个案例。对起源知之甚少,GP的临床病理特征或预后。SOX2和OCT4是最近公认的胚胎干细胞分化的标志物。这里,报道了SOX2和OCT4在11例GP发病中的作用,并描述了临床病理因素。
■这是一项为期六年(2017-2022年)的回顾性研究。所有的GP病例都是从档案中检索到的,确诊并记录临床病理因素.只要有的话,就注意到神经胶质原纤维酸蛋白(GFAP)和S100的免疫组织化学(IHC)研究。使用抗生物素蛋白-生物素技术对S0X2和0CT4进行IHC。
■确诊为GP11例。中位年龄为29岁,1/11例也患有结节性胶质瘤病。未成熟畸胎瘤8例,成熟囊性畸胎瘤3例。SOX2在GP的所有病灶中均呈阳性,而OCT4为阴性。这些病灶对GFAP和S100也呈阳性。
■GP的可能性应被视为一种差异,临床和放射学,在网膜结节的情况下。在手术时进行足够的采样对于排除转移或发展中的畸胎瘤综合征至关重要。SOX2,一种诱导神经分化的干细胞标记,可能与其他转录因子相关,在GP的发展中起着至关重要的作用。
UNASSIGNED: Gliomatosis peritonei (GP) is a rare entity characterized by multiple mature glial tissue implants in association with ovarian teratomas in the peritoneum and omentum. To date, only 100 cases have been published. Not much is known about the origin, clinicopathological profile or prognosis of GP. SOX2 and OCT4 are recently recognized markers of embryonic stem cell differentiation. Here, the role of SOX2 and OCT4 in the pathogenesis of 11 cases of GP are reported and clinicopathological factors are described.
UNASSIGNED: This was a retrospective study of six years duration (2017-2022). All the cases of GP were retrieved from archives, the diagnosis was confirmed and clinicopathological factors were noted. Immunohistochemical (IHC) investigation for glial fibrillary acid protein (GFAP) and S100 was noted wherever available. IHC for SOX2 and OCT4 was performed using an avidin-biotin technique.
UNASSIGNED: There were 11 cases of GP identified. The median age was 29 years and 1/11 cases had nodal gliomatosis as well. There were eight cases of immature
teratoma and three cases of mature cystic
teratoma. SOX2 was positive in all foci of GP, while OCT4 was negative. These foci were also positive for GFAP and S100.
UNASSIGNED: A possibility of GP should be considered as a differential, clinically and radiologically, in cases of omental nodularity. Adequate sampling at the time of surgery is essential to rule out metastasis or growing
teratoma syndrome. SOX2, a stem cell marker inducing neural differentiation, may play a crucial role in the development of GP in association with other transcription factors.