关键词: Cisplatin-resistance Germ cell tumors Retroperitoneal lymph node dissection (RPLND) Testicular cancer Tumor markers miRNA

Mesh : Humans Testicular Neoplasms / drug therapy genetics pathology Male MicroRNAs / genetics Neoplasms, Germ Cell and Embryonal / drug therapy genetics pathology Teratoma / drug therapy genetics pathology Biomarkers, Tumor / genetics analysis

来  源:   DOI:10.1016/j.ucl.2024.03.007

Abstract:
MicroRNAs (miRNAs) are emerging as highly sensitive and specific markers for testicular germ cell tumors (GCTs) across the spectrum of disease. However, their utility in specific clinical scenarios requires further study. Here, we review the current evidence for miRNAs as tumor markers for the evaluation of treatment response in patients undergoing chemotherapy for the treatment of advanced testicular GCT.
摘要:
microRNAs(miRNAs)正在成为睾丸生殖细胞肿瘤(GCTs)的高度敏感和特异性标志物。然而,它们在特定临床场景中的效用需要进一步研究.这里,我们回顾了目前关于miRNAs作为肿瘤标志物的证据,用于评估接受化疗以治疗晚期睾丸GCT的患者的治疗反应.
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