■本研究旨在探讨老年人甘油三酯与高密度脂蛋白胆固醇(TG/HDL-C)比值与相对握力的关系,为预防和控制肌肉减少症提供参考。
■对于这项横断面研究,从2011-2014年国家健康和营养调查(NHANES)数据库中提取了1,404名≥60岁个体的人口统计学和临床数据.相对握力的定义是每个手/体重指数(BMI)比率的最大读数之和。我们使用加权单变量线性回归和逐步回归分析来筛选协变量。使用加权单变量和多变量线性回归分析来探索TG/HDL-C比率与相对握力之间的关联。我们还在性别亚组中探索了这种关系,糖尿病(DM),心血管疾病(CVD),和关节炎。评价指标为β,置信区间为95%(CI)。
■共有1,306名老年人符合条件。在调整包括年龄在内的协变量后,性别,种族,婚姻状况,身体活动,DM,CVD,关节炎,和慢性肾病(CKD),我们发现TG/HDL-C比值与相对握力呈负相关(均p<0.05)。此外,TG/HDL-C比值升高也与女性的相对握力降低有关,没有DM,并且具有CVD(所有p<0.05)。
■随着TG/HDL-C比率的增加,老年人的相对握力明显下降,这表明TG/HDL-C比值可以在老年人群中密切监测,并且可能与肌肉减少症的预防和控制有关。
This study aims to explore the association between triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio and relative grip strength in older adults in order to provide some references for the prevention and control of sarcopenia.
For this cross-sectional study, the demographic and clinical data of 1,404 individuals aged ≥60 years old were extracted from the National Health and Nutrition Examination Survey (NHANES) database in 2011-2014. The definition of relative grip strength was the sum of the largest reading from each hand/body mass index (BMI) ratio. We used weighted univariate linear regression and stepwise regression analysis to screen the covariates. Weighted univariate and multivariate linear regression analyses were used to explore the association between the TG/HDL-C ratio and the relative grip strength. We also explored this relationship in subgroups of gender, diabetes mellitus (DM), cardiovascular disease (CVD), and arthritis. The evaluation index was β with 95% confidence intervals (CIs).
A total of 1,306 older adults were eligible. After adjusting for the covariates including age, gender, race, marital status, physical activity, DM, CVD, arthritis, and chronic kidney disease (CKD), we found that the TG/HDL-C ratio was negatively linked to the relative grip strength (all p < 0.05). Furthermore, the increased TG/HDL-C ratio was also related to the decreased relative grip strength in those who were women, not having DM, and having CVD (all p < 0.05).
With the increase in the TG/HDL-C ratio, the relative grip strength of older adults decreased significantly, indicating that the TG/HDL-C ratio could be closely monitored in the older adult population and may be associated with the prevention and control of sarcopenia.