Abstract：
OBJECTIVE: Few data exist regarding the gender differences in the relationship between triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio and cardiometabolic risk leading to atherosclerotic cardiovascular disease (ASCVD). We investigated, by gender, the association between the TG/HDL-C ratio and metabolic syndrome (MetS) and its components in the Japanese, who are less obese than their Western counterparts.
RESULTS: A population consisting of 10,373 participants (average age, 47.6 ± 12.6 years, 60.9 % men) at the Health Planning Center of Nihon University Hospital between April 2019 and March 2020 was studied using a cross-sectional study method. The TG/HDL-C ratio and proportion of visceral obesity increased approximately parallelly with age in women; however, these parameters did not change proportionally with age in men. Accordingly, receiver operating characteristic analysis revealed the accuracy of the TG/HDL-C ratio as a predictor of visceral obesity based on the Japanese MetS criteria (women vs. men: area under the curve, 0.797 vs. 0.712, p < 0.0001; sensitivity, 82.4 % vs. 59.9 %; specificity, 61.1 % vs. 71.1 %; cutoff value, 1.075 vs. 1.933, respectively). Furthermore, a higher TG/HDL-C ratio in women reflected the status of MetS and its components compared with men in multi-logistic regression analysis.
CONCLUSIONS: An increased TG/HDL-C ratio in women may be involved in MetS and its components compared to men. We may pay attention to visceral obesity and increased TG/HDL-C ratio to prevent ASCVD risk in women, even in the Japanese population, which generally contains a lower proportion of obesity than in Western populations.
RESULTS: A population consisting of 10,373 participants (average age, 47.6 ± 12.6 years, 60.9 % men) at the Health Planning Center of Nihon University Hospital between April 2019 and March 2020 was studied using a cross-sectional study method. The TG/HDL-C ratio and proportion of visceral obesity increased approximately parallelly with age in women; however, these parameters did not change proportionally with age in men. Accordingly, receiver operating characteristic analysis revealed the accuracy of the TG/HDL-C ratio as a predictor of visceral obesity based on the Japanese MetS criteria (women vs. men: area under the curve, 0.797 vs. 0.712, p < 0.0001; sensitivity, 82.4 % vs. 59.9 %; specificity, 61.1 % vs. 71.1 %; cutoff value, 1.075 vs. 1.933, respectively). Furthermore, a higher TG/HDL-C ratio in women reflected the status of MetS and its components compared with men in multi-logistic regression analysis.
CONCLUSIONS: An increased TG/HDL-C ratio in women may be involved in MetS and its components compared to men. We may pay attention to visceral obesity and increased TG/HDL-C ratio to prevent ASCVD risk in women, even in the Japanese population, which generally contains a lower proportion of obesity than in Western populations.
摘要：
目的：关于三酰甘油/高密度脂蛋白胆固醇（TG/HDL-C）比值与心血管代谢风险之间的性别差异导致动脉粥样硬化性心血管疾病（ASCVD）的数据很少。我们调查了,按性别,日本人的TG/HDL-C比值与代谢综合征（MetS）及其成分之间的关联，他们的肥胖程度低于西方同行。
结果：由10,373名参与者组成的人群（平均年龄，47.6±12.6年，60.9％的男性）在2019年4月至2020年3月期间在日本大学医院健康计划中心使用横断面研究方法进行了研究。女性的TG/HDL-C比值和内脏型肥胖比例随年龄增加而增加；然而，在男性中,这些参数没有随年龄成比例变化.因此，受试者工作特征分析显示，根据日本MetS标准，TG/HDL-C比值作为内脏肥胖预测指标的准确性(女性与男人:曲线下的面积，0.797vs.0.712，p<0.0001；灵敏度，82.4%vs.59.9％；特异性，61.1%vs.71.1%；截止值，1.075vs.分别为1.933）。此外，在多因素logistic回归分析中,与男性相比,女性较高的TG/HDL-C比值反映了MetS及其组分的状况.
结论：与男性相比，女性的TG/HDL-C比值增加可能与MetS及其组成部分有关。我们可能会注意内脏肥胖和TG/HDL-C比值升高，以预防女性ASCVD风险，即使在日本人口中，与西方人群相比，肥胖的比例通常较低。
结果：由10,373名参与者组成的人群（平均年龄，47.6±12.6年，60.9％的男性）在2019年4月至2020年3月期间在日本大学医院健康计划中心使用横断面研究方法进行了研究。女性的TG/HDL-C比值和内脏型肥胖比例随年龄增加而增加；然而，在男性中,这些参数没有随年龄成比例变化.因此，受试者工作特征分析显示，根据日本MetS标准，TG/HDL-C比值作为内脏肥胖预测指标的准确性(女性与男人:曲线下的面积，0.797vs.0.712，p<0.0001；灵敏度，82.4%vs.59.9％；特异性，61.1%vs.71.1%；截止值，1.075vs.分别为1.933）。此外，在多因素logistic回归分析中,与男性相比,女性较高的TG/HDL-C比值反映了MetS及其组分的状况.
结论：与男性相比，女性的TG/HDL-C比值增加可能与MetS及其组成部分有关。我们可能会注意内脏肥胖和TG/HDL-C比值升高，以预防女性ASCVD风险，即使在日本人口中，与西方人群相比，肥胖的比例通常较低。
