PDF(Pubmed)
Abstract：
OBJECTIVE: To identify patients who are at risk for a first cardiovascular event, mitigate the risk, and institute early intervention. The triglyceride to high-density lipoprotein-C (TG/HDL-C) ratio has been found to be a very useful biomarker for directing treatment and prevention therapy.
METHODS: This retrospective cross-sectional study included adult patients (aged >18 years) experiencing first-time acute coronary syndrome (ACS). We examined all patient databases for a definite diagnosis of angina, non-ST segment elevation myocardial infarction (NSTEMI), or ST-segment elevation myocardial infarction (STEMI). Lipid profiles were obtained prior to or at the time of admission.
RESULTS: A total of 265 patients were included in the study (mean age 57.83 ± 11.4 years) and 79.2% were men. Male gender, presence of diabetes, raised total cholesterol, raised low-density lipoprotein (LDL), and raised troponin level on admission were significantly positively correlated with STEMI (p=0.004, p=0.001, p<0.001, and p<0.001), whereas TG/HDL-C ratio was significantly negatively correlated with STEMI (p=0.048), while there was no significant results with NSTEMI (p=0.264) and angina (p=0.326). Total cholesterol and raised low-density lipoprotein (LDL) were significantly positively correlated with NSTEMI (p=0.013 and p=0.024).
CONCLUSIONS: Patients with first-time ACS may not have an increased TG/HDL-C ratio. High LDL levels had the most significant association with an ACS event, along with total cholesterol and diabetes. Further research is needed on a larger scale to determine the association of TG/HDL-C ratio with ACS and differentiate the different types of ACS events according to their clinical and laboratory characteristics.
METHODS: This retrospective cross-sectional study included adult patients (aged >18 years) experiencing first-time acute coronary syndrome (ACS). We examined all patient databases for a definite diagnosis of angina, non-ST segment elevation myocardial infarction (NSTEMI), or ST-segment elevation myocardial infarction (STEMI). Lipid profiles were obtained prior to or at the time of admission.
RESULTS: A total of 265 patients were included in the study (mean age 57.83 ± 11.4 years) and 79.2% were men. Male gender, presence of diabetes, raised total cholesterol, raised low-density lipoprotein (LDL), and raised troponin level on admission were significantly positively correlated with STEMI (p=0.004, p=0.001, p<0.001, and p<0.001), whereas TG/HDL-C ratio was significantly negatively correlated with STEMI (p=0.048), while there was no significant results with NSTEMI (p=0.264) and angina (p=0.326). Total cholesterol and raised low-density lipoprotein (LDL) were significantly positively correlated with NSTEMI (p=0.013 and p=0.024).
CONCLUSIONS: Patients with first-time ACS may not have an increased TG/HDL-C ratio. High LDL levels had the most significant association with an ACS event, along with total cholesterol and diabetes. Further research is needed on a larger scale to determine the association of TG/HDL-C ratio with ACS and differentiate the different types of ACS events according to their clinical and laboratory characteristics.
摘要：
目的：确定有首次心血管事件风险的患者，减轻风险，并进行早期干预。已经发现甘油三酯与高密度脂蛋白-C(TG/HDL-C)的比率是指导治疗和预防治疗的非常有用的生物标志物。
方法：本回顾性横断面研究纳入首次出现急性冠脉综合征（ACS）的成年患者（年龄>18岁）。我们检查了所有患者数据库，以明确诊断心绞痛，非ST段抬高型心肌梗死(NSTEMI),或ST段抬高型心肌梗死（STEMI）。在入院之前或入院时获得脂质概况。
结果：本研究共纳入265例患者（平均年龄57.83±11.4岁），79.2%为男性。男性,糖尿病的存在，总胆固醇升高,低密度脂蛋白（LDL）升高，入院时肌钙蛋白水平升高与STEMI呈显著正相关(p=0.004,p=0.001,p<0.001,p<0.001),而TG/HDL-C比值与STEMI呈显著负相关(p=0.048),而NSTEMI（p=0.264）和心绞痛（p=0.326）没有显着结果。总胆固醇和低密度脂蛋白(LDL)升高与NSTEMI呈显著正相关(p=0.013和p=0.024)。
结论：首次ACS患者可能没有TG/HDL-C比值升高。高LDL水平与ACS事件有最显著的关联，以及总胆固醇和糖尿病。需要更大规模的研究来确定TG/HDL-C比值与ACS的相关性，并根据其临床和实验室特征区分不同类型的ACS事件。
方法：本回顾性横断面研究纳入首次出现急性冠脉综合征（ACS）的成年患者（年龄>18岁）。我们检查了所有患者数据库，以明确诊断心绞痛，非ST段抬高型心肌梗死(NSTEMI),或ST段抬高型心肌梗死（STEMI）。在入院之前或入院时获得脂质概况。
结果：本研究共纳入265例患者（平均年龄57.83±11.4岁），79.2%为男性。男性,糖尿病的存在，总胆固醇升高,低密度脂蛋白（LDL）升高，入院时肌钙蛋白水平升高与STEMI呈显著正相关(p=0.004,p=0.001,p<0.001,p<0.001),而TG/HDL-C比值与STEMI呈显著负相关(p=0.048),而NSTEMI（p=0.264）和心绞痛（p=0.326）没有显着结果。总胆固醇和低密度脂蛋白(LDL)升高与NSTEMI呈显著正相关(p=0.013和p=0.024)。
结论：首次ACS患者可能没有TG/HDL-C比值升高。高LDL水平与ACS事件有最显著的关联，以及总胆固醇和糖尿病。需要更大规模的研究来确定TG/HDL-C比值与ACS的相关性，并根据其临床和实验室特征区分不同类型的ACS事件。
