METHODS: This retrospective cross-sectional study included adult patients (aged >18 years) experiencing first-time acute coronary syndrome (ACS). We examined all patient databases for a definite diagnosis of angina, non-ST segment elevation myocardial infarction (NSTEMI), or ST-segment elevation myocardial infarction (STEMI). Lipid profiles were obtained prior to or at the time of admission.
RESULTS: A total of 265 patients were included in the study (mean age 57.83 ± 11.4 years) and 79.2% were men. Male gender, presence of diabetes, raised total cholesterol, raised low-density lipoprotein (LDL), and raised troponin level on admission were significantly positively correlated with STEMI (p=0.004, p=0.001, p<0.001, and p<0.001), whereas TG/HDL-C ratio was significantly negatively correlated with STEMI (p=0.048), while there was no significant results with NSTEMI (p=0.264) and angina (p=0.326). Total cholesterol and raised low-density lipoprotein (LDL) were significantly positively correlated with NSTEMI (p=0.013 and p=0.024).
CONCLUSIONS: Patients with first-time ACS may not have an increased TG/HDL-C ratio. High LDL levels had the most significant association with an ACS event, along with total cholesterol and diabetes. Further research is needed on a larger scale to determine the association of TG/HDL-C ratio with ACS and differentiate the different types of ACS events according to their clinical and laboratory characteristics.
方法:本回顾性横断面研究纳入首次出现急性冠脉综合征(ACS)的成年患者(年龄>18岁)。我们检查了所有患者数据库,以明确诊断心绞痛,非ST段抬高型心肌梗死(NSTEMI),或ST段抬高型心肌梗死(STEMI)。在入院之前或入院时获得脂质概况。
结果:本研究共纳入265例患者(平均年龄57.83±11.4岁),79.2%为男性。男性,糖尿病的存在,总胆固醇升高,低密度脂蛋白(LDL)升高,入院时肌钙蛋白水平升高与STEMI呈显著正相关(p=0.004,p=0.001,p<0.001,p<0.001),而TG/HDL-C比值与STEMI呈显著负相关(p=0.048),而NSTEMI(p=0.264)和心绞痛(p=0.326)没有显着结果。总胆固醇和低密度脂蛋白(LDL)升高与NSTEMI呈显著正相关(p=0.013和p=0.024)。
结论:首次ACS患者可能没有TG/HDL-C比值升高。高LDL水平与ACS事件有最显著的关联,以及总胆固醇和糖尿病。需要更大规模的研究来确定TG/HDL-C比值与ACS的相关性,并根据其临床和实验室特征区分不同类型的ACS事件。