■干燥综合征(SS)是一种自身免疫性疾病,主要影响唾液和泪腺,并进一步导致口干和眼睛。近年来,关于SS治疗的知识正在迅速发展。本研究旨在使用文献计量学方法评估SS治疗的研究进展,并确定该领域的研究热点和新兴趋势。
■与SS治疗相关的出版物是从科学引文索引扩展(SCI-E)数据库中检索的。以下搜索项用于提取文档数据:TS=(干燥*或干燥*)和TS=(治疗*或治疗*或疾病管理)。选择了1900年至2022年以英文发表的文章和评论文章。手动筛选后,将出版物数据导出到纯文本文件中,并应用于合作网络分析,关键词分析,并利用CiteSpace进行参考共引分析。
■来自9063位作者的571种期刊的分析中包含了2038种出版物。自1992年以来,每年发表的研究和引用的次数显示出总体上升趋势。在这方面有一定程度的国家/区域合作,但是机构和作者之间的直接合作仍然缺乏。出版物最多的国家是美国,其次是中国和日本。通过对关键词和参考文献的分析,总结出5个与SS相关的治疗方法作为研究热点,包括免疫抑制和抗炎治疗,再生疗法,基因治疗,手术治疗,和对症治疗。其中,B细胞,T细胞,粘膜相关不变T(MAIT)细胞,间充质干细胞(MSCs),利妥昔单抗,belimumab,细胞靶向治疗,免疫抑制和抗炎治疗是该领域的新兴趋势。
■这项研究从全新的角度对SS的治疗进行了基于数据的客观介绍。对智力基础的分析,研究热点,以及该领域的新兴趋势将有助于未来的研究和治疗决策,这最终将使SS患者受益。
UNASSIGNED: Sjogren\'s syndrome (SS) is an autoimmune disease that mainly affects the salivary and lacrimal glands and further leads to dry mouth and eyes. In recent years, knowledge about the treatment of SS is developing rapidly. This study aims to assess research progress on SS treatment using a bibliometric approach and to identify research hotspots and emerging trends in this area.
UNASSIGNED: The publications related to the treatment of SS were retrieved from the Science Citation Index Expanded (SCI-E) database. The following search terms were used to extract document data: TS=(Sjogren* OR Sicca*) AND TS= (Treat* OR Therap* OR Disease Management). Articles and review articles published in English from 1900 to 2022 were selected. After the manual screening, the publication data were exported to a plain text file and applied for cooperative network analysis, keyword analysis, and reference co-citation analysis by using CiteSpace.
UNASSIGNED: A total of 2038 publications were included in the analysis from 571 journals by 9063 authors. The annual number of published studies and times cited showed an overall upward trend since 1992. There was a degree of national/regional collaboration in this area, but direct collaboration between institutions and authors was still lacking. The country with the highest number of publications was in the United States, followed by China and Japan. Five SS-related treatments as the research hotspots were summarized by analyzing keywords and references, including immunosuppressive and anti-inflammatory therapy, regenerative therapy, gene therapy, surgical treatment, and symptomatic treatment. Among them, B cells, T cells, mucosal-associated invariant T (MAIT) cells, mesenchymal stem cells (MSCs), rituximab, belimumab, cell-target therapy, and immunosuppressive and anti-inflammatory therapy were emerging trends in this field.
UNASSIGNED: This study conducted a data-based and objective introduction to the treatment of SS from a fresh perspective. An analysis of the intellectual bases, research hotspots, and emerging trends in the field will contribute to future research and treatment decisions, which will ultimately benefit SS patients.