Abstract：
Primary Sjögren\'s syndrome (pSS), a chronic autoimmune condition, has been associated with an increased risk of several cancers. This study aims to delve into the relationship between pSS and the potential development of non-Hodgkin\'s lymphoma (NHL) utilizing an in-depth systematic review and meta-analysis approach. To thoroughly explore the topic, we conducted a thorough examination of the literature, drawing from reputable databases such as ProQuest, PubMed, Web of Science, Cochrane, and Google Scholar. Our data collection spanned until February 8, 2024, with no time limitation. Data were analyzed with Stata 14 software at a significance threshold of p < 0.05. We examined 15 cohort studies encompassing a total of 50,308 individuals from 1997 to 2023. The findings revealed a substantial link between pSS and the risk of NHL, evident across all demographics. Specifically, the standardized incidence ratio (SIR) was generally 8.78 (95% CI 5.51, 13.99), with similar trends observed in both men (SIR, 6.29; 95% CI 1.93, 20.51) and women (SIR, 9.60; 95% CI 5.89, 15.63). Additionally, the SIR (10.50 (95% CI 7, 15.75)), HR (2.82 (95% CI 1.28, 6.18)), and OR (10.50 (95% CI 3.04, 36.28)) indices further supported this association. Furthermore, the risk of non-NHL associated with pSS was noticeable across different age groups of 40-49 years (SIR, 30.13; 95% CI 14.62, 62.08), 50-59 years (SIR, 9.12; 95% CI 5.13, 16.19), and 60-69 years (SIR, 9; 95% CI 4.68, 17.32). pSS substantively augments the likelihood of NHL manifestation. It notably impacts females and those in earlier stages of adulthood with more acuity than males and older cohorts.
摘要：
原发性干燥综合征（pSS），慢性自身免疫性疾病,与多种癌症的风险增加有关。本研究旨在利用深入的系统评价和荟萃分析方法探讨pSS与非霍奇金淋巴瘤（NHL）的潜在发展之间的关系。为了彻底探索这个话题，我们对文献进行了彻底的研究，从ProQuest等知名数据库中提取，PubMed,WebofScience,科克伦,谷歌学者。我们的数据收集时间一直持续到2024年2月8日，没有时间限制。用Stata14软件以p<0.05的显著性阈值分析数据。我们检查了15项队列研究，包括1997年至2023年的50,308名个体。研究结果揭示了pSS与NHL风险之间的实质性联系，在所有人口统计学中都很明显。具体来说,标准化发病率(SIR)一般为8.78(95%CI5.51，13.99)，在两个男人身上观察到类似的趋势(SIR，6.29；95%CI1.93，20.51)和女性(SIR，9.60；95%CI5.89，15.63）。此外,SIR（10.50（95%CI7，15.75）），HR（2.82（95%CI1.28，6.18）），和OR(10.50(95%CI3.04，36.28))指数进一步支持这一关联。此外，与pSS相关的非NHL的风险在40-49岁的不同年龄组中很明显(SIR，30.13；95%CI14.62，62.08），50-59岁(先生，9.12；95%CI5.13，16.19），60-69岁(先生，9；95%CI4.68，17.32）。pSS实质上增加了NHL表现的可能性。它特别影响女性和成年早期阶段的女性，其敏锐度比男性和老年群体更高。
