SCOPUS

scopus
  • 文章类型: Journal Article
    二恶英类化合物,被世界卫生组织(WHO)公认为环境中最持久的有毒化学物质之一,与世界各地的各种职业活动和工业事故有关。这项研究的目的是检查和介绍有关二恶英的研究出版物,指出当前的研究趋势,确定研究差距,并强调该领域未来探索的潜在途径。相关研究文章的研究期限为1923年至2022年12月31日,这些文章来自Scopus数据库。分析涉及确定该领域的关键贡献者和主题的可视化,主题,和国际合作。使用VOSviewer软件(版本1.6.20)进行可视化分析。Scopus数据库中记录了总共11,620种有关二恶英的出版物。这些文件的主要类别包括9780篇原始文章,占总出版物的84.17%。美国在出版物数量上领先,3992(34.35%),其次是日本,1429(12.3%),中国,1005(8.65%),德国,974(8.38%)。在2002年之前,该领域的学术关注主要集中在健康影响上,环境命运,和四氯二苯并对二恶英(TCDD)的毒性机理。然而,自2002年以来,研究重点发生了明显变化,突出了与多氯二苯并对二恶英(PCDD)和多氯二苯并呋喃(PFDF)的健康影响和环境命运有关的主题的出现。本研究首次对二恶英进行了全面的定量文献计量分析。这些发现表明,在过去30年中,二恶英文献的总体增长显着增加。这些发现可能对指导和组织与二恶英有关的后续调查至关重要。
    Dioxin-like compounds, recognized by the World Health Organization (WHO) as among the most enduring toxic chemical substances in the environment, are linked to various occupational activities and industrial accidents worldwide. The aim of this study was to examine and present research publications on dioxins, pinpoint current research trends, identify research gaps, and highlight potential avenues for future exploration in the field. The study period for relevant research articles ranged from 1923 to December 31, 2022, and these articles were sourced from the Scopus database. The analysis involved the identification of key contributors to the field and the visualization of topics, themes, and international collaboration. VOSviewer software (version 1.6.20) was used for visualization analysis. A total of 11,620 publications on dioxins were documented in the Scopus database. The predominant category of these documents comprised 9780 original articles, which represents 84.17% of the total publications. The United States lead in the number of publications, with 3992 (34.35%), followed by Japan, with 1429 (12.3%), China, with 1005 (8.65%), and Germany, with 974 (8.38%). Before 2002, scholarly attention in this field focused primarily on the health effects, environmental fate, and mechanism of toxicity of tetrachlorodibenzo-p-dioxin (TCDD). However, a noticeable change in research focus has been observed since 2002, highlighting the emergence of a topic related to the health effects and environmental fate of polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PFDFs). This study is the first to conduct a comprehensive quantitative bibliometric analysis of dioxins over time. These findings indicate a significant increase in the overall growth of the dioxin literature over the past 30 years. These findings may prove crucial in guiding and organizing subsequent investigations related to dioxins.
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  • 文章类型: Journal Article
    进行文献计量学分析,作为对与月经癫痫相关的出版物的全面审查,并讨论该领域的知识现状。
    从Scopus数据库检索了1956年至2022年之间发布的出版物。使用R包和VOSviewer进行文献计量分析,以显示期刊的数据和网络,组织,作者,国家,和关键词。2022年10月15日进行的分析总共产生了320项细化研究。
    出版物数量大幅增加,特别是在过去的20年里。月经癫痫相关出版物主要来自医学和其他学科领域,美国拥有最大的出版物产量。作者的合作程度很低,组织,和国家层面,尤其是在亚洲大陆。出版物仍然很少,特别是在实践准则上,风险评估,和药物相关的研究。根据关键字分析,文献计量分析确定了未来研究的可能主题。
    月经癫痫相关文献至关重要,但仍然不足,需要进一步研究。
    UNASSIGNED: To perform a bibliometric analysis as a comprehensive review of publications associated with catamenial epilepsy and discuss the current state of knowledge in the field.
    UNASSIGNED: Publications published between 1956 and 2022 were retrieved from the Scopus database. Bibliometric analysis was performed using the R package and VOSviewer to show the data and network of journals, organizations, authors, countries, and keywords. The analysis conducted on October 15, 2022, yielded a total of 320 refinement studies.
    UNASSIGNED: The number of publications has escalated significantly, particularly in the last 20 years. Catamenial epilepsy-related publications originated mostly from medicine and other subject areas, with the United States having the largest publication output. Collaboration is low at the author, organizational, and national levels, especially in the Asian continent. Publications remain scarce, particularly on practice guidelines, risk assessment, and medication-related research. Based on a keyword analysis, a bibliometric analysis identified possible themes for future investigation.
    UNASSIGNED: Catamenial epilepsy-related literature is crucial but still insufficient, and further studies are required.
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  • 文章类型: Journal Article
    背景:尽管精神病理学和社交媒体使用方面的研究取得了进展,没有全面的综述审查了有关此类研究的已发表论文,并考虑了其如何受到2019年冠状病毒病(COVID-19)爆发的影响.
    目的:探讨COVID-19爆发前后精神病理学和社交媒体使用的研究现状。
    方法:我们使用Bibliometrix(R软件包)对来自WebofScienceCoreCollection的4588项相关研究进行了科学计量分析,PubMed,和Scopus数据库。
    结果:这样的研究成果在COVID-19之前是稀缺的,但在大流行之后随着一些高影响力文章的发表而爆发。主要作者和机构,主要位于发达国家,保持他们的核心地位,很大程度上不受COVID-19的影响;然而,在COVID-19之后,发展中国家的研究生产和合作显着增加。通过对关键词的分析,我们确定了该领域的常用方法,与特定人群一起,精神病理学状况,和临床治疗。研究人员越来越关注心理病理状态中的性别差异,并将COVID-19与抑郁症密切相关,抑郁症检测成为一种新趋势。精神病理学和社交媒体使用研究的发展在国家/地区之间是不平衡和不协调的,未来应进行更深入的临床研究。
    结论:在COVID-19之后,人们对心理健康问题的关注程度增加,对社交媒体使用和突发公共卫生事件的影响的重视也在不断变化。
    BACKGROUND: Despite advances in research on psychopathology and social media use, no comprehensive review has examined published papers on this type of research and considered how it was affected by the coronavirus disease 2019 (COVID-19) outbreak.
    OBJECTIVE: To explore the status of research on psychopathology and social media use before and after the COVID-19 outbreak.
    METHODS: We used Bibliometrix (an R software package) to conduct a scientometric analysis of 4588 relevant studies drawn from the Web of Science Core Collection, PubMed, and Scopus databases.
    RESULTS: Such research output was scarce before COVID-19, but exploded after the pandemic with the publication of a number of high-impact articles. Key authors and institutions, located primarily in developed countries, maintained their core positions, largely uninfluenced by COVID-19; however, research production and collaboration in developing countries increased significantly after COVID-19. Through the analysis of keywords, we identified commonly used methods in this field, together with specific populations, psychopathological conditions, and clinical treatments. Researchers have devoted increasing attention to gender differences in psychopathological states and linked COVID-19 strongly to depression, with depression detection becoming a new trend. Developments in research on psychopathology and social media use are unbalanced and uncoordinated across countries/regions, and more in-depth clinical studies should be conducted in the future.
    CONCLUSIONS: After COVID-19, there was an increased level of concern about mental health issues and a changing emphasis on social media use and the impact of public health emergencies.
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  • 文章类型: Journal Article
    本研究使用文献计量技术和社会网络分析来评估全球城市中318种有关空气质量管理的出版物。从Scopus数据库检索相关数据,并使用VOSviewer1.6.7工具进行分析。分析包括出版物的数量,引文分析,研究区域分析,以及1975年至2022年11月6日期间最常见的关键字。此外,根据聚类分析的结果,我们开发了可实现更具体关键词分类的共现网络。可视化显示了关键术语之间的现有关系,研究领域,以及有关城市空气质量管理的出版物。中国,美国,在研究期间,英国在科学出版物的数量和联系的总体强度方面处于领先地位。最有成效的期刊是《全环境科学》,其次是大气环境,和国际环境研究与公共卫生杂志。描述了该研究的一些局限性,并为将来的研究提出了建议,以增加研究范围并促进城市空气质量管理。
    This study uses bibliometric techniques and social network analysis to evaluate 318 publications on air quality management in cities worldwide. The relevant data were retrieved from the Scopus database and analyzed using the VOSviewer 1.6.7 tools. The analysis included the number of publications, citation analyses, research study area analyses, and the most common keywords from 1975 to November 6, 2022. In addition, based on the results of the cluster analysis, we developed co-occurrence networks that enable a more specific keyword classification. The visualization showed the existing relationships between key terms, research study areas, and publications dealing with air quality management in cities. China, the United States, and the United Kingdom led in terms of the number of scientific publications and overall strength of connections during the study period. The most productive journal was Science of the Total Environment, followed by Atmospheric Environment, and the International Journal of Environmental Research and Public Health. Several limitations of the study are described and recommendations are made for future studies to increase the scope of studies and facilitate urban air quality management.
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  • 文章类型: Journal Article
    海洋潜力不仅储存经济潜力,但也保留了生态的其他潜力,地缘政治,国际冲突的潜在地缘战略,使海上安全对世界上所有国家都非常重要。本文旨在使用Scopus数据库通过文献计量方法分析海上安全或海上安全。使用的主要搜索关键字是使用VOSviewer应用程序评估多个群集的“海事安全”。同时,NVivo12应用程序被用作分析wordcloud的工具。简而言之,与海事安全相关的最高研究年份发生在2019年,美国成为最常撰写有关海事安全文献的国家。此外,大多数研究趋势都在调查海事安全,重点是通过进行集群映射来预测海事部门出现的风险和威胁的国家战略。总而言之,这篇文章最终指出,海事安全需要国际定义才能进行未来的研究。
    Marine potential does not only store economic potential, but also preserves other potentials from ecological, geopolitical, geostrategic to the potential for international conflicts that make security at sea very essential for all countries in the world. This article aims to analyze maritime security or maritime security with a bibliometric approach using the Scopus database. The main search keyword used was \"Maritime Security\" employing the VOSviewer application for evaluating several clusters. Meanwhile, the NVivo12 application was used as a tool for analyzing wordcloud. In a nutshell, the highest year of research related to maritime security occurred in 2019 and America became the country which most often wrote literature on maritime security. In addition, most research trends are investigating maritime security with a focus on countries\' strategies to anticipate risks and threats that arise in the maritime sector by conducting cluster mapping. To sum up, this article conclusively informs that maritime security requires the international definition for future studies.
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  • 文章类型: Review
    激光碎石术在全球范围内越来越重要,并且是一个动态发展的领域,每年都有大量新的和全面的研究。最近,已经出现了明显的转向采用各种激光器,如钬:钇-铝-石榴石(Ho:YAG)和铕纤维(TFL)激光器。因此,我们的目标是进行文献计量分析,以分析科学出版物中研究活动的关键领域,这些出版物集中于激光技术在尿石症中的应用。2023年12月25日,使用Scopus数据库对1978年至2022年的文献进行了搜索,以探索与激光技术在尿石症治疗中的应用有关的研究。使用VOSviewer软件(版本1.6.20)进行可视化分析。我们检查了符合指定标准的962种出版物,其中791篇(82.22%)为原创文章。对检索到的出版物的分析表明,从1978年到2022年,研究产出持续增长;2003年之后出现了特别值得注意的激增。特别是,美国宣称是生产力最高的国家,贡献211篇文章(21.93%)。然而,根据19.08的调整指数,印度的研究生产率最高。在欧洲地区,324份出版物(占总数的33.68%)来自25个国家。在1978年至2022年之间,《内分泌杂志》的贡献最大(n=96,9.98%)。被引用最多的论文检查了钬:钇铝石榴石(Ho:YAG)激光器的有效性,虽然随后的研究集中在使用thu光纤激光器(TFL),一种新兴的激光技术,已获得越来越多的认可。共现分析显示,三个不同的集群侧重于激光技术的类型,微创方法,成功率/术后并发症。这项全面的调查探讨了使用激光治疗尿石症的全球前景。这篇综述支持使用各种类型的激光技术治疗尿石症的新兴临床概念。此外,根据这项研究的结果,研究人员应该关注的热点问题是针对手术方法使用不同类型的激光碎石术,成功率和并发症。
    Laser lithotripsy is gaining global prominence and is a dynamically progressing field marked by a continual influx of new and comprehensive research each year. Recently, there has been a noticeable shift toward the adoption of various kinds of lasers, such as holmium: yttrium-aluminum-garnet (Ho:YAG) and thulium fiber (TFL) lasers. Consequently, we aim to conduct a bibliometric analysis to analyze key areas of research activity within scientific publications that center on the utilization of laser techniques in urolithiasis. A search of the literature spanning from 1978 to 2022 was carried out on 25 December 2023 using the Scopus database to explore research related to the application of laser techniques for urolithiasis treatment. Visualization analysis was performed using VOSviewer software (version 1.6.20). We examined 962 publications that met the specified criteria, 791 (82.22%) of which were original articles. The analysis of the retrieved publications indicated a consistent increase in research output from 1978 to 2022; a particularly noteworthy surge occurred after 2003. In particular, the U.S. claimed the leading position as the most productive country, contributing 211 articles (21.93%). However, India had the highest research productivity according to the adjustment index of 19.08. In the European region, 324 publications (33.68% of the total) originated from 25 countries. The Journal of Endourology contributed the most between 1978 and 2022 (n = 96, 9.98%). The most cited paper examined the effectiveness of holmium: yttrium-aluminum-garnet (Ho:YAG) lasers, while a subsequent study focused on the use of a thulium fiber laser (TFL), an emerging laser technology that has gained increased recognition. Co-occurrence analysis revealed three distinct clusters focusing on the types of laser technology, minimally invasive approaches, and success rate/postoperative complications. This comprehensive investigation delves into the global landscape of laser use for the treatment of urolithiasis. This review supports the emerging clinical concept of using various types of laser technology for urolithiasis treatment. Moreover, the hot issues that researchers should focus on based on the findings of this study are the use of different types of laser lithotripsy in view of the surgical approach, success rate and complications.
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  • 文章类型: Journal Article
    这项全面的文献计量研究调查了可持续供应链创新(SSCI)研究,检查它的演变,确定关键贡献者,揭示新兴趋势。使用健壮的Scopus数据集分析1158篇英语SSCI文章,揭示了值得注意的期刊,作者,机构,全球贡献。研究结果表明,自1999年以来,研究产出持续增加,过去十年中出现了显着增长。网络分析和基于密度的空间聚类确定了六个SSCI研究集群:商业中的可持续性和责任,导航创新和中断,可持续商业战略,环境可持续性和创新,可持续粮食系统和环境影响,和可持续的商业动态。这些集群突出了不断发展的可持续性和供应链管理(SCM)领域的多样性,有助于深入了解SSCI研究格局,并强调可持续性和SCM主题之间的相互联系,可能导致更全面的理论模型。此外,这种理解有助于企业预测新兴趋势并在SSCI中实施最佳实践。此外,认可活跃的机构和全球贡献者,为促进战略合作提供了实用的见解。
    This comprehensive bibliometric study investigates Sustainable Supply Chain Innovation (SSCI) research, examining its evolution, identifying key contributors, and unveiling emerging trends. Analyzing 1158 English-language SSCI articles using the robust Scopus dataset exposes noteworthy journals, authors, institutions, and global contributions. The findings suggest a consistent increase in research output since 1999, with a notable surge in the past decade. Network analysis and density-based spatial clustering identified six SSCI research clusters: Sustainability and Responsibility in Business, Navigating Innovation and Disruption, Sustainable Business Strategies, Environmental Sustainability and Innovation, Sustainable Food Systems and Environmental Impact, and Sustainable Business Dynamics. These clusters highlight the diverse nature of the evolving Sustainability and Supply Chain Management (SCM) field, contributing to a thorough understanding of the SSCI research landscape and emphasizing interconnections between sustainability and SCM themes, potentially leading to more comprehensive theoretical models. Furthermore, this understanding aids businesses in anticipating emerging trends and implementing optimal practices in SSCI. Moreover, recognizing active institutions and global contributors provides practical insights for fostering strategic collaborations.
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  • 文章类型: Journal Article
    目的:进行文献计量网络分析,以探索立即植入植入(IIP)的研究格局,并提供对其趋势和贡献者的见解。
    方法:Scopus数据库被用作书目来源,并实施搜索策略以识别相关研究文章。提取了各种文献计量参数,包括出版年份,journal,作者,引文,和资金。分析涉及检查作者身份模式,国际合作,证据水平,Altmetric数据,和资金分析。
    结果:我们在IIP研究中确定了6.49%的稳定年增长率。对研究成果贡献最大的三个国家是美国,意大利,和中国。根据出版物和引文指标确定多产作者。观察到不同国家之间的国际合作。证据水平分析显示,超过30%的文章属于更高水平的证据(1级和2级)。Altmetric数据分析表明,引文计数与Altmetric注意力得分(AAS)之间没有显着相关性,相反,与门捷利读者计数的显著关联。资金和开放获取并未显着影响论文的文献计量指数。
    结论:IIP的研究重点一直在发展,正如本研究的指数增长率所表明的那样。只有大约16%的文章符合一级证据,因此,强调该领域高质量水平的研究性学习不足。现代指数可以用作新的文献计量指标,因为它们还涵盖社交媒体和在线关注得分。
    OBJECTIVE: To conduct a bibliometric network analysis to explore the research landscape of immediate implant placement (IIP) and provide insights into its trends and contributors.
    METHODS: The Scopus database was utilized as the bibliographic source, and a search strategy was implemented to identify relevant research articles. Various bibliometric parameters were extracted, including publication year, journal, authors, citations, and funding. The analysis involved examining authorship patterns, international collaborations, level of evidence, Altmetric data, and funding analysis.
    RESULTS: We identified a steady annual growth rate of 6.49% in IIP research. The top three countries contributing to research output were the USA, Italy, and China. Prolific authors were identified based on publication and citation metrics. International collaborations among different countries were observed. The level of evidence analysis revealed that over 30% of the articles fell into higher levels of evidence (levels 1 and 2). Altmetric data analysis indicated no significant correlations between citation counts and Altmetric Attention Score (AAS), and conversely a significant association with Mendeley readers count. Funding and open access did not significantly impact the bibliometric indices of the papers.
    CONCLUSIONS: The focus of research on IIP has been evolving as indicated by an exponential growth rate in this study. Only approximately 16% of the articles fit into level 1 evidence, therefore, emphasizing on higher quality level research study shortage in this field. Modern indices can be used as new bibliometric indicators as they also cover social media and online attention scores.
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  • 文章类型: Journal Article
    背景:现代监狱制度非常重视,至少在正式和成文安排方面,为囚犯提供医疗保健和康复服务。我们研究的目的是分析WebofScience(WoS)和SCOPUS医学数据库,以搜索和评估讨论成年男性囚犯的口腔状况和牙科治疗需求的可用文献。方法:使用以下术语:囚犯或囚犯;口腔健康,口腔状态;牙周状态,牙周病;口腔卫生;龋齿;粘膜;唾液。根据PICO(人口,干预,control,和结果)标准。研究方案是根据2020年PRISMA指南制定的,未注册。分析了讨论成年被监禁患者的口腔状况和牙科治疗需求的现有文献。纳入标准如下:2012年1月1日至2022年期间以英文发表的文章;讨论18岁以上成年囚犯口腔状况的文章(硬组织,牙周状况,唾液,粘膜状况,或口腔卫生);可提供全文的文章;以及根据纽卡斯尔-渥太华量表评估为令人满意的文章。结果:共鉴定出934篇文献,其中9项纳入了系统审查。两篇文章讨论了欧洲(俄罗斯和芬兰)囚犯的口腔状况,亚洲有四名受审囚犯(三名在印度,一名在沙特阿拉伯),两名在非洲(尼日利亚)接受检查的囚犯,和一个检查囚犯在美洲(巴西)。结论:囚犯的口头地位已在现有文献中得到广泛讨论。在囚犯中,观察到龋齿和牙周病的发生率较高,口腔卫生较差。可以得出结论,囚犯应该可以从牙周医生和牙髓医生那里获得专门的治疗。
    Background: Modern penitentiary systems attach great importance, at least in the area of formal and codified arrangements, to providing inmates with access to health care and rehabilitation. The aim of our study was to analyze the Web of Science (WoS) and SCOPUS medical databases in order to search for and evaluate the available literature discussing the oral status and dental treatment needs of adult male prisoners. Methods: The following terms were used: prisoners or inmates; oral health, oral status; periodontal status, periodontal disease; oral hygiene; caries; mucosa; and saliva. The studies were screened based on their title and abstract according to the PICO (population, intervention, control, and outcome) criteria. The research protocol was prepared on the basis of the 2020 PRISMA guidelines and was not registered. The available literature discussing the oral status and dental treatment needs of adult imprisoned patients was analyzed. The inclusion criteria were as follows: articles published in English between 1 January 2012 and 2022; articles discussing the oral cavity status of adult inmates over 18 years old (hard tissues, periodontal status, saliva, mucosa condition, or oral hygiene); articles with a full text available; and articles that were assessed as satisfactory according to the Newcastle-Ottawa Scale. Results: A total of 934 articles were identified, out of which 9 were included in the systematic review. Two articles discussed the oral condition of prisoners in Europe (Russia and Finland), four examined prisoners in Asia (three in India and one in Saudi Arabia), two examined prisoners in Africa (Nigeria), and one examined prisoners in the Americas (Brazil). Conclusions: The oral status of prisoners has been widely discussed in the available literature. Among inmates, a higher frequency of both caries and periodontal disease along with poorer oral hygiene were observed. It can be concluded that inmates should have access to specialized treatment from periodontists and endodontists.
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  • 文章类型: Journal Article
    背景:Nobiletin是广泛存在于柑橘类果皮中的天然聚甲氧基类黄酮。它已被证明发挥抗肿瘤的作用,抗炎,抗氧化,抗凋亡和改善心血管功能。越来越多的证据表明,川陈皮素在呼吸系统疾病(RDs)的治疗中起着重要作用。
    目的:这篇综述旨在研究金胆素对视网膜病变的治疗潜力,比如肺癌,COPD,肺纤维化,哮喘,肺部感染,急性肺损伤,2019年冠状病毒病和肺动脉高压。
    方法:我们从PubMed数据库中检索了直到2023年6月26日用英语的相关文献的大量文献,WebofScience,和Scopus数据库。\"川陈皮素与肺\"的关键词,“景别素与呼吸系统疾病”,“景别素与慢性呼吸系统疾病”,\“景别素和代谢物\”,“金黄素和药代动力学”,成对地搜索了“景别素和毒性”。从上述数据库共检索到298篇文献。排除重复项和审核后,53名被列入本次审查。
    结果:我们发现治疗机制基于不同的信号通路。首先,通过调节相关通路或关键靶点抑制肿瘤细胞的增殖,抑制肿瘤细胞的侵袭和迁移,像Bcl-2,PD-L1,PARP,和Akt/GSK3β/β-catenin在肺癌治疗中的应用。其次,通过靶向介导炎症的经典信号通路治疗COPD和ALI。此外,现有的研究结果表明,川陈皮素通过调节mTOR通路发挥PF治疗的作用。
    结论:具有广泛的药理活性,高效低毒,景别素可作为一种潜在的预防和治疗药物。这些发现将有助于进一步研究川陈皮素的分子机制,并有助于在临床前和临床水平上深入研究川陈皮素治疗RD。
    BACKGROUND: Nobiletin is a natural polymethoxylated flavonoid widely present in citrus fruit peels. It has been demonstrated to exert the effects of anti-tumor, anti-inflammation, anti-oxidative, anti-apoptotic and improve cardiovascular function. Increasing evidences suggest that nobiletin plays an important role in respiratory diseases (RDs) treatment.
    OBJECTIVE: This review aimed to investigate the therapeutic potential of nobiletin against RDs, such as lung cancer, COPD, pulmonary fibrosis, asthma, pulmonary infection, acute lung injury, coronavirus disease 2019, and pulmonary arterial hypertension.
    METHODS: We retrieved extensive literature of relevant literatures in English until June 26, 2023 from the database of PubMed, Web of Science, and Scopus databases. The keywords of \"nobiletin and lung\", \"nobiletin and respiratory disease\", \"nobiletin and chronic respiratory diseases\", \"nobiletin and metabolites\", \"nobiletin and pharmacokinetics\", \"nobiletin and toxicity\" were searched in pairs. A total of 298 literatures were retrieved from the above database. After excluding the duplicates and reviews, 53 were included in the current review.
    RESULTS: We found that the therapeutic mechanisms are based on different signaling pathways. Firstly, nobiletin inhibited the proliferation and suppressed the invasion and migration of cancer cells by regulating the related pathway or key target, like Bcl-2, PD-L1, PARP, and Akt/GSK3β/β-catenin in lung cancer treatment. Secondly, nobiletin treats COPD and ALI by targeting classical signaling pathway mediating inflammation. Besides, the available findings show that nobiletin exerts the effect of PF treatment via regulating mTOR pathway.
    CONCLUSIONS: With the wide range of pharmacological activities, high efficiency and low toxicity, nobiletin can be used as a potential agent for preventing and treating RDs. These findings will contribute to further research on the molecular mechanisms of nobiletin and facilitate in-depth studies on nobiletin at both preclinical and clinical levels for the treatment of RDs.
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