Abstract：
BACKGROUND: Nobiletin is a natural polymethoxylated flavonoid widely present in citrus fruit peels. It has been demonstrated to exert the effects of anti-tumor, anti-inflammation, anti-oxidative, anti-apoptotic and improve cardiovascular function. Increasing evidences suggest that nobiletin plays an important role in respiratory diseases (RDs) treatment.
OBJECTIVE: This review aimed to investigate the therapeutic potential of nobiletin against RDs, such as lung cancer, COPD, pulmonary fibrosis, asthma, pulmonary infection, acute lung injury, coronavirus disease 2019, and pulmonary arterial hypertension.
METHODS: We retrieved extensive literature of relevant literatures in English until June 26, 2023 from the database of PubMed, Web of Science, and Scopus databases. The keywords of \"nobiletin and lung\", \"nobiletin and respiratory disease\", \"nobiletin and chronic respiratory diseases\", \"nobiletin and metabolites\", \"nobiletin and pharmacokinetics\", \"nobiletin and toxicity\" were searched in pairs. A total of 298 literatures were retrieved from the above database. After excluding the duplicates and reviews, 53 were included in the current review.
RESULTS: We found that the therapeutic mechanisms are based on different signaling pathways. Firstly, nobiletin inhibited the proliferation and suppressed the invasion and migration of cancer cells by regulating the related pathway or key target, like Bcl-2, PD-L1, PARP, and Akt/GSK3β/β-catenin in lung cancer treatment. Secondly, nobiletin treats COPD and ALI by targeting classical signaling pathway mediating inflammation. Besides, the available findings show that nobiletin exerts the effect of PF treatment via regulating mTOR pathway.
CONCLUSIONS: With the wide range of pharmacological activities, high efficiency and low toxicity, nobiletin can be used as a potential agent for preventing and treating RDs. These findings will contribute to further research on the molecular mechanisms of nobiletin and facilitate in-depth studies on nobiletin at both preclinical and clinical levels for the treatment of RDs.
OBJECTIVE: This review aimed to investigate the therapeutic potential of nobiletin against RDs, such as lung cancer, COPD, pulmonary fibrosis, asthma, pulmonary infection, acute lung injury, coronavirus disease 2019, and pulmonary arterial hypertension.
METHODS: We retrieved extensive literature of relevant literatures in English until June 26, 2023 from the database of PubMed, Web of Science, and Scopus databases. The keywords of \"nobiletin and lung\", \"nobiletin and respiratory disease\", \"nobiletin and chronic respiratory diseases\", \"nobiletin and metabolites\", \"nobiletin and pharmacokinetics\", \"nobiletin and toxicity\" were searched in pairs. A total of 298 literatures were retrieved from the above database. After excluding the duplicates and reviews, 53 were included in the current review.
RESULTS: We found that the therapeutic mechanisms are based on different signaling pathways. Firstly, nobiletin inhibited the proliferation and suppressed the invasion and migration of cancer cells by regulating the related pathway or key target, like Bcl-2, PD-L1, PARP, and Akt/GSK3β/β-catenin in lung cancer treatment. Secondly, nobiletin treats COPD and ALI by targeting classical signaling pathway mediating inflammation. Besides, the available findings show that nobiletin exerts the effect of PF treatment via regulating mTOR pathway.
CONCLUSIONS: With the wide range of pharmacological activities, high efficiency and low toxicity, nobiletin can be used as a potential agent for preventing and treating RDs. These findings will contribute to further research on the molecular mechanisms of nobiletin and facilitate in-depth studies on nobiletin at both preclinical and clinical levels for the treatment of RDs.
摘要：
背景：Nobiletin是广泛存在于柑橘类果皮中的天然聚甲氧基类黄酮。它已被证明发挥抗肿瘤的作用，抗炎，抗氧化，抗凋亡和改善心血管功能。越来越多的证据表明，川陈皮素在呼吸系统疾病（RDs）的治疗中起着重要作用。
目的：这篇综述旨在研究金胆素对视网膜病变的治疗潜力，比如肺癌，COPD,肺纤维化，哮喘,肺部感染,急性肺损伤，2019年冠状病毒病和肺动脉高压。
方法：我们从PubMed数据库中检索了直到2023年6月26日用英语的相关文献的大量文献，WebofScience,和Scopus数据库。\"川陈皮素与肺\"的关键词,“景别素与呼吸系统疾病”，“景别素与慢性呼吸系统疾病”，\“景别素和代谢物\”，“金黄素和药代动力学”，成对地搜索了“景别素和毒性”。从上述数据库共检索到298篇文献。排除重复项和审核后，53名被列入本次审查。
结果：我们发现治疗机制基于不同的信号通路。首先,通过调节相关通路或关键靶点抑制肿瘤细胞的增殖,抑制肿瘤细胞的侵袭和迁移,像Bcl-2，PD-L1，PARP，和Akt/GSK3β/β-catenin在肺癌治疗中的应用。其次,通过靶向介导炎症的经典信号通路治疗COPD和ALI。此外,现有的研究结果表明，川陈皮素通过调节mTOR通路发挥PF治疗的作用。
结论：具有广泛的药理活性，高效低毒,景别素可作为一种潜在的预防和治疗药物。这些发现将有助于进一步研究川陈皮素的分子机制，并有助于在临床前和临床水平上深入研究川陈皮素治疗RD。
目的：这篇综述旨在研究金胆素对视网膜病变的治疗潜力，比如肺癌，COPD,肺纤维化，哮喘,肺部感染,急性肺损伤，2019年冠状病毒病和肺动脉高压。
方法：我们从PubMed数据库中检索了直到2023年6月26日用英语的相关文献的大量文献，WebofScience,和Scopus数据库。\"川陈皮素与肺\"的关键词,“景别素与呼吸系统疾病”，“景别素与慢性呼吸系统疾病”，\“景别素和代谢物\”，“金黄素和药代动力学”，成对地搜索了“景别素和毒性”。从上述数据库共检索到298篇文献。排除重复项和审核后，53名被列入本次审查。
结果：我们发现治疗机制基于不同的信号通路。首先,通过调节相关通路或关键靶点抑制肿瘤细胞的增殖,抑制肿瘤细胞的侵袭和迁移,像Bcl-2，PD-L1，PARP，和Akt/GSK3β/β-catenin在肺癌治疗中的应用。其次,通过靶向介导炎症的经典信号通路治疗COPD和ALI。此外,现有的研究结果表明，川陈皮素通过调节mTOR通路发挥PF治疗的作用。
结论：具有广泛的药理活性，高效低毒,景别素可作为一种潜在的预防和治疗药物。这些发现将有助于进一步研究川陈皮素的分子机制，并有助于在临床前和临床水平上深入研究川陈皮素治疗RD。
