目的:复发性口疮性口炎(RAS)被称为复发性口疮性溃疡,是口腔中常见的疼痛性溃疡。有人认为血液学参数似乎被认为是病因因素。所以,本荟萃分析和系统综述旨在研究RAS与血液学参数之间的关系.
方法:使用包括Scopus在内的在线国际数据库发现了相关研究,科学直接,WebofScience(ISI),PubMed,和谷歌学者搜索引擎在2000年至2023年10月之间。所有论文的质量由NOS检查表确定。主要研究结果之间的不均一性用I平方指数评估,发表偏倚用Egger检验和漏斗图进行。此外,我们进行了敏感性分析,以检查每一项主要研究对总体估计值的影响.此外,使用Stata软件Ver进行统计分析.11.
结果:通过结合初步研究的结果,维生素B12、铁蛋白、叶酸,血红蛋白,病例组(RAS患者)和对照组(健康组)之间95%置信区间(CI)的铁和锌指数估计为-0.52(-0.89,-0.14),-0.20(-0.51,0.11),-0.42(-0.95,0.11),-0.58(-0.90,-0.27),0.01(-0.12,0.15),分别为-0.33(-0.81、0.14)。维生素B12、铁蛋白、叶酸,铁缺乏和血红蛋白(Hb)水平降低报告为2.93(2.28,3.78),2.50(1.48,4.22),1.51(0.53,4.29),1.46(0.70,3.03),和2.14(1.38,3.32),比健康个体更容易发生RAS。
结论:荟萃分析结果表明,病例组维生素B12血清SMD和Hb水平为52%。我们的结果还表明,维生素B12,铁蛋白缺乏,病例组Hb水平下降分别为健康组的2.93、2.50和2.14倍。
OBJECTIVE: Recurrent Aphthous Stomatitis (RAS) known as recurrent aphthous ulcer is a common and painful ulcerations in oral cavity. It has been suggested that hematological parameters seems to be considered as an etiologic factor. So, this meta-analysis and systematic review was aimed to examine the relationship between RAS and hematological parameters.
METHODS: Relevant studies were found using online international databases including Scopus, Science direct, Web of science (ISI), PubMed, and Google Scholar search engine between 2000 and October 2023. The quality of all papers was determined by NOS checklist. Heterogeneity between the results of primary studies was evaluated with I-square index and publication bias was performed by Egger\'s test and funnel plots. Also, sensitivity analysis was done to check the effect of each of the primary studies on the overall estimate. Also, the statistical analyses were done using Stata software Ver. 11.
RESULTS: By combining the results of primary studies, the standardized mean difference (SMD) of vitamin B12, ferritin, folic acid, hemoglobin, iron and zinc indices with a 95% confidence interval (CI) between the case (patients with RAS) and control (Healthy) groups were estimated -0.52(-0.89, -0.14), -0.20(-0.51, 0.11), -0.42(-0.95, 0.11), -0.58(-0.90, -0.27), 0.01(-0.12, 0.15), -0.33(-0.81, 0.14) respectively. The patients with vitamin B12, ferritin, folic acid, and iron deficiencies and reduced hemoglobin (Hb) level reported 2.93(2.28, 3.78), 2.50(1.48, 4.22), 1.51(0.53, 4.29), 1.46(0.70, 3.03), and 2.14(1.38, 3.32), times more susceptible to develop RAS than healthy individuals.
CONCLUSIONS: The results of the meta-analysis indicated that the SMD of vitamin B12 serum and Hb levels in the case group was 52%. Our result have also showed that the odds ratio of vitamin B12, ferritin deficiencies, and decreased Hb level in case group was 2.93, 2.50, and 2.14 times more than healthy group.