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Abstract：
OBJECTIVE: The purpose of this study was to determine the therapeutic effect of the Punica granatum (PG) flower on recurrent aphthous stomatitis in comparison with corticosteroid therapy.
METHODS: This cross-over randomized clinical trial was conducted on the patients who had been referred to Shiraz Dental School for their RAS in 2021. All the participants used both P. granatum flower tablets and Triadent a month apart for wash-out time and all compared themselves. In the experimental group, 30 patients received pomegranate flower tablets, three tablets daily, for 6 days. In the control group, oral paste Triadent has been prescribed three times a day for 6 days. The visual analog scale (VAS) and the size of RAS were evaluated on Days 0-6. Data were analyzed by SPSS version 21. The Wilcoxon test was used.
RESULTS: The mean age of participants was 27.8 ± 14.77 years old. In this study, 15 patients (50%) were men and 15 patients (50%) were women. The mean value of VAS after using prescribed treatment in both evaluated groups on all days was significantly different such that the VAS values were lower for PG flower tablets than Triadent (p value < 0.05). The size of oral lesions in participants who used PG flower tablets was significantly less than those who used Triadent on all evaluation days (p value < 0.05) except on Day 1 (p value = 0.29). The descending slope of VAS from Days 1 to 6 for both Triadent and PG flower tablet users was significant and noticeable. (p value < 0.05).
CONCLUSIONS: According to the result of this study, both P. granatum flower tablet and Triadent are useful in reducing the size, period of healing, and VAS of patients with RAS, but the PG flower tablet is more effective.
METHODS: This cross-over randomized clinical trial was conducted on the patients who had been referred to Shiraz Dental School for their RAS in 2021. All the participants used both P. granatum flower tablets and Triadent a month apart for wash-out time and all compared themselves. In the experimental group, 30 patients received pomegranate flower tablets, three tablets daily, for 6 days. In the control group, oral paste Triadent has been prescribed three times a day for 6 days. The visual analog scale (VAS) and the size of RAS were evaluated on Days 0-6. Data were analyzed by SPSS version 21. The Wilcoxon test was used.
RESULTS: The mean age of participants was 27.8 ± 14.77 years old. In this study, 15 patients (50%) were men and 15 patients (50%) were women. The mean value of VAS after using prescribed treatment in both evaluated groups on all days was significantly different such that the VAS values were lower for PG flower tablets than Triadent (p value < 0.05). The size of oral lesions in participants who used PG flower tablets was significantly less than those who used Triadent on all evaluation days (p value < 0.05) except on Day 1 (p value = 0.29). The descending slope of VAS from Days 1 to 6 for both Triadent and PG flower tablet users was significant and noticeable. (p value < 0.05).
CONCLUSIONS: According to the result of this study, both P. granatum flower tablet and Triadent are useful in reducing the size, period of healing, and VAS of patients with RAS, but the PG flower tablet is more effective.
摘要：
目的：本研究的目的是确定与皮质类固醇治疗相比，石榴花（PG）花对复发性口疮性口炎的治疗效果。
方法：这项交叉随机临床试验是对2021年因RAS转诊到设拉子牙科学校的患者进行的。所有参与者都间隔一个月使用石榴花片剂和Triadent冲洗时间，并进行了比较。在实验组中,30例患者接受石榴花片，每天三片，6天。在对照组中，Triadent口服膏剂已每天开三次，共6天。在第0-6天评估视觉模拟量表(VAS)和RAS的大小。数据采用SPSS21版进行分析。使用Wilcoxon检验。
结果：参与者的平均年龄为27.8±14.77岁。在这项研究中,15名患者（50％）为男性，15名患者（50％）为女性。在所有天的两个评估组中使用规定治疗后的VAS的平均值显著不同,使得PG花片剂的VAS值低于Triadent(p值<0.05)。除了第1天（p值=0.29）外，在所有评估日（p值<0.05），使用PG花片的参与者的口腔病变大小均显着小于使用Triadent的参与者。Triadent和PG花平板电脑用户的VAS从第1天到第6天的下降斜率是显着且明显的。(p值<0.05)。
结论：根据本研究的结果，石榴花片和Triadent都有助于减小尺寸，愈合期,和RAS患者的VAS，但是PG花片更有效。
方法：这项交叉随机临床试验是对2021年因RAS转诊到设拉子牙科学校的患者进行的。所有参与者都间隔一个月使用石榴花片剂和Triadent冲洗时间，并进行了比较。在实验组中,30例患者接受石榴花片，每天三片，6天。在对照组中，Triadent口服膏剂已每天开三次，共6天。在第0-6天评估视觉模拟量表(VAS)和RAS的大小。数据采用SPSS21版进行分析。使用Wilcoxon检验。
结果：参与者的平均年龄为27.8±14.77岁。在这项研究中,15名患者（50％）为男性，15名患者（50％）为女性。在所有天的两个评估组中使用规定治疗后的VAS的平均值显著不同,使得PG花片剂的VAS值低于Triadent(p值<0.05)。除了第1天（p值=0.29）外，在所有评估日（p值<0.05），使用PG花片的参与者的口腔病变大小均显着小于使用Triadent的参与者。Triadent和PG花平板电脑用户的VAS从第1天到第6天的下降斜率是显着且明显的。(p值<0.05)。
结论：根据本研究的结果，石榴花片和Triadent都有助于减小尺寸，愈合期,和RAS患者的VAS，但是PG花片更有效。
