PDF(Pubmed)
Abstract：
BACKGROUND: Recurrent aphthous stomatitis (RAS) is a common chronic inflammatory oral disease that negatively impacts the quality of life. Current therapies aim to reduce pain and healing process yet challenges such as rapid loss due to salivary flushing in topical drugs and adverse effects due to prolonged use of systemic medications require further notice. Low-level laser therapy is reported with immediate pain relief and faster healing thus preserving the potential for optimal treatment modalities. This review critically analyses and summarizes the effectiveness of LLLT in reducing pain scores and healing time of RAS.
METHODS: A systematic search was conducted in ScienceDirect, PubMed, and Scopus using keywords of low-level laser therapy, photo-biomodulation therapy, and recurrent aphthous stomatitis. RCTs between 1967 to June 2022, presenting characteristics of the laser and reporting pain score and/or healing time of RAS after irradiation were included. Animal studies and recurrent aphthous ulcers with a history of systemic conditions were excluded. Studies were critically appraised using the RoB 2 tool. A meta-analysis was performed using inverse variance random effects.
RESULTS: Fourteen trials with a total of 664 patients were included. Reduced pain was reported in 13 studies, while shortened healing time was presented in 4. The pooling of two studies after CO2 irradiation demonstrated faster healing time compared to placebo (MD - 3.72; 95% CI - 4.18, - 3.25).
CONCLUSIONS: Pain score and healing time of RAS were reduced after irradiation with LLLT. RoB resulted in \"some concerns\" urging well-designed RCTs with larger samples to further assess each laser application for comparison.
BACKGROUND: PROSPERO CRD42022355737.
METHODS: A systematic search was conducted in ScienceDirect, PubMed, and Scopus using keywords of low-level laser therapy, photo-biomodulation therapy, and recurrent aphthous stomatitis. RCTs between 1967 to June 2022, presenting characteristics of the laser and reporting pain score and/or healing time of RAS after irradiation were included. Animal studies and recurrent aphthous ulcers with a history of systemic conditions were excluded. Studies were critically appraised using the RoB 2 tool. A meta-analysis was performed using inverse variance random effects.
RESULTS: Fourteen trials with a total of 664 patients were included. Reduced pain was reported in 13 studies, while shortened healing time was presented in 4. The pooling of two studies after CO2 irradiation demonstrated faster healing time compared to placebo (MD - 3.72; 95% CI - 4.18, - 3.25).
CONCLUSIONS: Pain score and healing time of RAS were reduced after irradiation with LLLT. RoB resulted in \"some concerns\" urging well-designed RCTs with larger samples to further assess each laser application for comparison.
BACKGROUND: PROSPERO CRD42022355737.
摘要：
背景：复发性口疮性口炎（RAS）是一种常见的慢性炎症性口腔疾病，对生活质量产生负面影响。目前的疗法旨在减少疼痛和愈合过程，但挑战如由于局部药物的唾液潮红而导致的快速损失和由于长期使用全身药物而导致的不良反应需要进一步注意。据报道，低水平激光治疗可立即缓解疼痛并更快愈合，从而保留了最佳治疗方式的潜力。这篇综述批判性地分析和总结了LLLT在降低RAS疼痛评分和愈合时间方面的有效性。
方法：在ScienceDirect中进行了系统搜索，PubMed,和Scopus使用低级激光治疗的关键词，光生物调节疗法，和复发性口疮性口炎。包括1967年至2022年6月之间的RCT，呈现激光特征并报告辐照后RAS的疼痛评分和/或愈合时间。排除了动物研究和有全身性疾病史的复发性口疮。使用RoB2工具对研究进行了严格评估。使用逆方差随机效应进行荟萃分析。
结果：纳入14项试验，共664例患者。13项研究报告疼痛减轻，而缩短的愈合时间出现在4。与安慰剂相比，CO2照射后两项研究的合并显示出更快的愈合时间（MD-3.72；95％CI-4.18，-3.25）。
结论：用LLLT照射后，RAS的疼痛评分和愈合时间减少。RoB引起了“一些担忧”，敦促设计良好的RCT具有更大的样品，以进一步评估每种激光应用进行比较。
背景：PROSPEROCRD420223555737。
方法：在ScienceDirect中进行了系统搜索，PubMed,和Scopus使用低级激光治疗的关键词，光生物调节疗法，和复发性口疮性口炎。包括1967年至2022年6月之间的RCT，呈现激光特征并报告辐照后RAS的疼痛评分和/或愈合时间。排除了动物研究和有全身性疾病史的复发性口疮。使用RoB2工具对研究进行了严格评估。使用逆方差随机效应进行荟萃分析。
结果：纳入14项试验，共664例患者。13项研究报告疼痛减轻，而缩短的愈合时间出现在4。与安慰剂相比，CO2照射后两项研究的合并显示出更快的愈合时间（MD-3.72；95％CI-4.18，-3.25）。
结论：用LLLT照射后，RAS的疼痛评分和愈合时间减少。RoB引起了“一些担忧”，敦促设计良好的RCT具有更大的样品，以进一步评估每种激光应用进行比较。
背景：PROSPEROCRD420223555737。
