糖尿病是一种常见的慢性代谢紊乱,其特征在于长时间的葡萄糖水平升高。持续的高血糖会导致糖尿病并发症,如视网膜病变,肾病,和神经病,和心血管并发症,如缺血性心脏病,外周血管疾病,糖尿病性心肌病,中风,等。有许多研究表明,各种多酚影响葡萄糖稳态,并可以帮助减轻与糖尿病相关的并发症。
■这篇综述着重于各种膳食多酚在减轻糖尿病引起的心血管并发症中的可能作用。这篇综述还旨在概述ROS产生(由于糖尿病)之间的相互关系,炎症,糖化应激,和心血管并发症以及膳食多酚的抗高血糖作用。
■各种科学数据库,包括Scopus,WebofScience,谷歌学者,PubMed,科学直接,SpringerLink,和Wiley在线图书馆用于搜索符合纳入和排除标准的文章。
■本综述列出了基于各种临床前和临床研究的几种多酚,这些多酚具有抗高血糖潜力以及对心血管并发症的保护功能。
■一些临床前和临床研究表明,各种膳食多酚可能是减轻糖尿病相关心血管并发症的有希望的干预措施。
UNASSIGNED: Diabetes mellitus is a common chronic metabolic disorder that is characterized by increased levels of glucose for prolonged periods of time. Incessant hyperglycemia leads to diabetic complications such as retinopathy, nephropathy, and neuropathy, and cardiovascular complications such as ischemic heart disease, peripheral vascular disease, diabetic cardiomyopathy, stroke, etc. There are many studies that suggest that various
polyphenols affect glucose homeostasis and can help to attenuate the complications associated with diabetes.
UNASSIGNED: This review focuses on the possible role of various dietary
polyphenols in palliating diabetes-induced cardiovascular complications. This review also aims to give an overview of the interrelationship among ROS production (due to diabetes), inflammation, glycoxidative stress, and cardiovascular complications as well as the anti-hyperglycemic effects of dietary
polyphenols.
UNASSIGNED: Various scientific databases including Scopus, Web of Science, Google Scholar, PubMed, Science Direct, Springer Link, and Wiley Online Library were used for searching articles that complied with the inclusion and exclusion criteria.
UNASSIGNED: This review lists several
polyphenols based on various pre-clinical and clinical studies that have anti-hyperglycemic potential as well as a protective function against cardiovascular complications.
UNASSIGNED: Several pre-clinical and clinical studies suggest that various dietary
polyphenols can be a promising intervention for the attenuation of diabetes-associated cardiovascular complications.