PDF(Pubmed)
Abstract：
Natural compounds such as polyphenols play several positive roles in maintaining the oxidative and inflammatory capacity of cells, which leads to their potential use as anticancer therapeutics. There is promising evidence for the in vitro and in vivo anticancer activity of many polyphenols, including resveratrol and quercetin, specifically in the treatment of colorectal cancer (CRC). There is a clear association between resveratrol and quercetin in interfering with the mechanistic pathways involved in CRC, such as Wnt, P13K/AKT, caspase-3, MAPK, NF-κB, etc. These molecular pathways establish the role of resveratrol and quercetin in controlling cancer cell growth, inducing apoptosis, and inhibiting metastasis. The major bottleneck in the progression of the use of resveratrol and quercetin as anticancer therapeutics is their reduced bioavailability in vivo because of their rapid metabolism in humans. Recent advancements in various nanotechnological formulations are promising for overcoming these bioavailability issues. Various nanoformulations of resveratrol and quercetin have shown an optimistic impact on reducing the solubility and improving the stability of resveratrol and quercetin in vivo. A combinatorial approach using nanoformulations of resveratrol with quercetin could potentially increase the impact of resveratrol in controlling CRC cell proliferation. This review discusses the mechanism of resveratrol and quercetin, the two bioactive polyphenolics, in colon cancer, with an emphasis on various types of nanoformulations of the two molecules targeting colon cancer. It also explores the synergistic effect of combining resveratrol and quercetin in various nanoformulations, targeting colon cancer. This research delves into the enhanced pharmacokinetics and potential chemotherapeutic benefits of these bioactive polyphenolics when used together in innovative ways.
摘要：
天然化合物如多酚在维持细胞的氧化和炎症能力方面发挥着积极作用。这导致了它们作为抗癌疗法的潜在用途。有许多多酚的体外和体内抗癌活性的有希望的证据，包括白藜芦醇和槲皮素,特别是在结直肠癌（CRC）的治疗中。白藜芦醇和槲皮素在干扰涉及CRC的机制途径中存在明显的关联，比如Wnt,P13K/AKT,caspase-3,MAPK,NF-κB,等。这些分子途径确立了白藜芦醇和槲皮素在控制癌细胞生长中的作用，诱导细胞凋亡，并抑制转移。白藜芦醇和槲皮素用作抗癌治疗剂的进展中的主要瓶颈是它们在体内的生物利用度降低,这是因为它们在人体内的快速代谢。各种纳米技术制剂的最新进展有望克服这些生物利用度问题。白藜芦醇和槲皮素的各种纳米制剂对降低白藜芦醇和槲皮素在体内的溶解度和改善稳定性显示出乐观的影响。使用白藜芦醇与槲皮素的纳米制剂的组合方法可能潜在地增加白藜芦醇在控制CRC细胞增殖中的影响。本文综述了白藜芦醇和槲皮素的作用机制,两种生物活性多酚，在结肠癌中，重点是针对结肠癌的两种分子的各种类型的纳米制剂。它还探讨了白藜芦醇和槲皮素在各种纳米制剂中的协同作用，靶向结肠癌。这项研究探讨了这些生物活性多酚以创新方式一起使用时增强的药代动力学和潜在的化疗益处。
