PDF(Pubmed)
Abstract：
Polyphenols are the most prevalent naturally occurring phytochemicals in the human diet and range in complexity from simple molecules to high-molecular-weight polymers. They have a broad range of chemical structures and are generally categorized as \"neuroprotective\", \"anti-inflammatory\", and \"antioxidant\" given their main function of halting disease onset and promoting health. Research has shown that some polyphenols and their metabolites can penetrate the blood-brain barrier and hence increase neuroprotective signaling and neurohormonal effects to provide anti-inflammatory and antioxidant effects. Therefore, multi-targeted modulation of polyphenols may prevent the progression of neuropsychiatric disorders and provide a new practical therapeutic strategy for difficult-to-treat neuropsychiatric disorders. Therefore, multi-target modulation of polyphenols has the potential to prevent the progression of neuropsychiatric disorders and provide a new practical therapeutic strategy for such nervous system diseases. Herein, we review the therapeutic benefits of polyphenols on autism-spectrum disorders, anxiety disorders, depression, and sleep disorders, along with in vitro and ex vivo experimental and clinical trials. Although their methods of action are still under investigation, polyphenols are still seldom employed directly as therapeutic agents for nervous system disorders. Comprehensive mechanistic investigations and large-scale multicenter randomized controlled trials are required to properly evaluate the safety, effectiveness, and side effects of polyphenols.
摘要：
多酚是人类饮食中最普遍的天然存在的植物化学物质，其复杂性从简单分子到高分子量聚合物。它们具有广泛的化学结构，通常被归类为“神经保护”，“抗炎”，和“抗氧化剂”，因为它们具有阻止疾病发作和促进健康的主要功能。研究表明，一些多酚及其代谢物可以穿透血脑屏障，从而增加神经保护信号和神经激素作用，从而提供抗炎和抗氧化作用。因此,多靶点调控多酚可预防神经精神疾病的进展,并为难以治疗的神经精神疾病提供新的实用治疗策略.因此,多酚的多靶点调控有可能预防神经精神疾病的进展，并为此类神经系统疾病提供新的实用治疗策略。在这里，我们回顾了多酚对自闭症谱系障碍的治疗益处，焦虑症,抑郁症,和睡眠障碍，以及体外和离体实验和临床试验。尽管他们的行动方法仍在调查中，多酚仍然很少直接用作神经系统疾病的治疗剂。需要全面的机制研究和大规模的多中心随机对照试验来正确评估安全性，有效性,和多酚的副作用。
